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Colistin sulfate / hydrocortisone / neomycin / thonzonium bromide otic Disease Interactions

There are 4 disease interactions with colistin sulfate / hydrocortisone / neomycin / thonzonium bromide otic:

Major

Neomycin (otic) (applies to colistin sulfate/hydrocortisone/neomycin/thonzonium bromide otic) perforated tympanic membrane

Major Potential Hazard, High plausibility.

Like other aminoglycosides, neomycin is potentially ototoxic, both to vestibular and to auditory functions. Therapy with neomycin otic preparations should be administered cautiously in patients with chronic otitis media or a perforated tympanic membrane. The risk of ototoxicity may be increased if medication enters the middle ear.

References

  1. "Product Information. Mycifradin (neomycin)." Emerson Laboratories, Texarkana, TX.
Major

Otic agents (applies to colistin sulfate/hydrocortisone/neomycin/thonzonium bromide otic) perforated tympanic membrane

Major Potential Hazard, High plausibility. Applicable conditions: Chronic Otitis Media, Chronic Otitis Media, Chronic Otitis Media

The use of medications that are intended for the treatment of otitis externa or other conditions of the external ear canal should generally be avoided, or otherwise approached with caution, in patients with a perforated tympanic membrane due to the risk of toxicity from medication that may get into the middle ear. Caution is also advised in patients with longstanding, chronic otitis media because of the possibility of a perforated tympanic membrane in such patients.

References

  1. "Multum Information Services, Inc. Expert Review Panel"
  2. Behrman R, Kliegman R, Arvin A, Nelson W, eds. "Nelson Textbook of Pediatrics. 15th ed." Philadelphia, PA: W.B. Saunders Company (1996):
Major

Otic corticosteroids (applies to colistin sulfate/hydrocortisone/neomycin/thonzonium bromide otic) viral infections

Major Potential Hazard, High plausibility. Applicable conditions: Herpes Simplex Otitis Externa, Herpes Zoster Otitis Externa

The use of otic preparations containing corticosteroids is contraindicated in patients with viral infections of the external canal including varicella and herpes simplex otitis externa. Corticosteroids may decrease host resistance to infectious agents, thus prolonging the course and/or exacerbating the severity of the infection while encouraging the development of new or secondary infection. Normally, corticosteroids may be administered with caution provided it is accompanied by appropriate anti-infective agents. However, otic preparations that are currently available lack effective antiviral agents.

References

  1. American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association; (1994):
Moderate

Topical aminoglycosides (applies to colistin sulfate/hydrocortisone/neomycin/thonzonium bromide otic) burns

Moderate Potential Hazard, High plausibility. Applicable conditions: Burns - External

Topical aminoglycosides should not be used on serious burns. When applied locally, aminoglycosides are generally not absorbed to a significant extent through intact skin but readily absorbed through denuded, burned, or granulating skin. Systemic adverse effects of aminoglycosides include nephrotoxicity and ototoxicity to vestibular and auditory functions. In general, topical aminoglycosides should not be used on large areas of the body or for more than 7 days without medical supervision.

References

  1. "Product Information. Myciguent (neomycin topical)." Pharmacia and Upjohn, Kalamazoo, MI.

Colistin sulfate / hydrocortisone / neomycin / thonzonium bromide otic drug interactions

There are 21 drug interactions with colistin sulfate / hydrocortisone / neomycin / thonzonium bromide otic

More about colistin sulfate / hydrocortisone / neomycin / thonzonium bromide otic

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.