Tybost Disease Interactions
There is 1 disease interaction with Tybost (cobicistat).
Cobicistat (applies to Tybost) creatinine clearance
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
Cobicistat has shown to decrease creatinine clearance without affecting actual renal glomerular function and no dose adjustment is required in patients with renal impairment, including those with severe renal impairment. However, this effect should be considered when interpreting changes in estimated creatinine clearance in patients initiating cobicistat when there is presence of renal impairment or in patients receiving other drugs that need to be monitored with estimated creatinine clearance. Patients who experience a confirmed increase of serum creatinine of 0.4 mg/dL from baseline should be closely monitored for renal safety.
References (1)
- (2014) "Product Information. Tybost (cobicistat)." Gilead Sciences
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Tybost drug interactions
There are 498 drug interactions with Tybost (cobicistat).
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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