Clomiphene Disease Interactions
There are 5 disease interactions with clomiphene:
Clomiphene (applies to clomiphene) abnormal uterine bleeding
Major Potential Hazard, High plausibility.
The use of clomiphene is contraindicated in patients with undiagnosed, abnormal genital bleeding. Patients should be evaluated to ensure that neoplastic lesions are not present.
Clomiphene (applies to clomiphene) hepatic dysfunction
Major Potential Hazard, High plausibility. Applicable conditions: Liver Disease
The use of clomiphene is contraindicated in patients with liver disease or history of hepatic dysfunction.. Clomiphene undergoes enterohepatic circulation and is metabolized by the liver. The serum concentration of clomiphene may be increased and the half-life prolonged in patients with compromised hepatic function.
Clomiphene (applies to clomiphene) pituitary activity
Major Potential Hazard, High plausibility. Applicable conditions: Pituitary Tumor, Brain/Intracranial Tumor, Thyroid Disease, Adrenal Insufficiency
The use of clomiphene is contraindicated in patients with uncontrolled thyroid or adrenal dysfunction or an organic intracranial lesion such as a pituitary tumor. Clomiphene interacts with estrogen receptors in various tissues, including the pituitary, the response of which is an increase in the release of pituitary gonadotropins.
Clomiphene (applies to clomiphene) uncontrolled adrenal dysfunction
Major Potential Hazard, High plausibility. Applicable conditions: Adrenal Insufficiency, Hyperadrenocorticism, Adrenal Tumor, Hyperaldosteronism
The use of clomiphene is contraindicated in patients with uncontrolled adrenal function. Alterations of adrenal function can impede pregnancy. Clomiphene therapy can result in alteration in steroid synthesis and/or fluid regulation.
Clomiphene (applies to clomiphene) hyperlipidemia
Moderate Potential Hazard, Moderate plausibility.
Cases of hypertriglyceridemia have been reported in patients receiving clomiphene treatment. Preexisting or family history of hyperlipidemia and use of higher than recommended dose and/or longer duration of treatment with clomiphene citrate are associated with a risk of hypertriglyceridemia. Periodic monitoring of plasma triglycerides is recommended in patients with preexisting or family history of hyperlipidemia. Pretreatment screening of triglyceride levels is recommended in patients initiating clomiphene citrate therapy.
Clomiphene drug interactions
There are 2 drug interactions with clomiphene
Clomiphene alcohol/food interactions
There is 1 alcohol/food interaction with clomiphene
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- Drug class: synthetic ovulation stimulants
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|