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Sensipar (cinacalcet) Disease Interactions

There are 3 disease interactions with Sensipar (cinacalcet):


Cinacalcet (Includes Sensipar) ↔ Hypocalcemia

Moderate Potential Hazard, Moderate plausibility

Applies to: Hypocalcemia

Cinacalcet lowers serum calcium, and therefore patients should be carefully monitored for the occurrence of hypocalcemia. Potential manifestations of hypocalcemia include paresthesias, myalgias, cramping, tetany, and convulsions. Cinacalcet treatment should not be initiated if serum calcium is less than the lower limit of the normal range (8.4 mg/dL). Monitor serum calcium 1 week after treatment initiation or dose adjustment, and once every month once the maintenance dose has been established.


Cinacalcet (Includes Sensipar) ↔ Hypotension

Moderate Potential Hazard, Moderate plausibility

Applies to: Hypotension, Heart Disease

Postmarketing safety surveillance studies have reported cases of hypotension, worsening heart failure and/or arrhythmias in patients with impaired cardiac function receiving cinacalcet. A causal relationship could not been excluded and this may be mediated by reductions in serum calcium. Cinacalcet should be used with caution in patients with hypotension or preexisting impaired cardiac function.


Cinacalcet (Includes Sensipar) ↔ Seizures

Moderate Potential Hazard, Moderate plausibility

Applies to: Seizures

Cinacalcet may lower seizure threshold in patients with a history of seizures. Serum calcium levels should be closely monitored in patients receiving cinacalcet, particularly in patients with history of seizure disorders.

Sensipar (cinacalcet) drug Interactions

There are 266 drug interactions with Sensipar (cinacalcet)

Sensipar (cinacalcet) alcohol/food Interactions

There is 1 alcohol/food interaction with Sensipar (cinacalcet)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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