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Cerliponase alfa Disease Interactions

There are 2 disease interactions with cerliponase alfa.

Major

Cerliponase alfa (applies to cerliponase alfa) hydrocephalus

Major Potential Hazard, Moderate plausibility. Applicable conditions: CNS Disorder

The use of cerliponase alfa is contraindicated in patients with ventriculoperitoneal shunts and those patients with acute intraventricular access device-related complications such as leakage, device failure, or device-related infection.

References

  1. (2017) "Product Information. Brineura (cerliponase alfa)." BioMarin Pharmaceutical Inc
Moderate

Cerliponase alfa (applies to cerliponase alfa) arrhythmias

Moderate Potential Hazard, Moderate plausibility.

The use of cerliponase alfa may cause cardiovascular complications. It is recommended to monitor vital signs (blood pressure, heart rate) before infusion starts, periodically during infusion, and post-infusion. Perform electrocardiogram (ECG) monitoring during infusion in patients with a history of conduction abnormalities. In patients without cardiac abnormalities, regular 12-lead ECG evaluations should be performed every 6 months.

References

  1. (2017) "Product Information. Brineura (cerliponase alfa)." BioMarin Pharmaceutical Inc

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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