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Hemabate (carboprost) Disease Interactions

There are 7 disease interactions with Hemabate (carboprost):

Major

Carboprost (Includes Hemabate) ↔ Cardiovascular Dysfunction

Severe Potential Hazard, High plausibility

Applies to: Ischemic Heart Disease, Myocardial Infarction, Hypertension, Hypotension, History - Myocardial Infarction

The use of carboprost is contraindicated in patients with uncontrolled or acute cardiovascular dysfunction. Carboprost induces contraction of smooth muscle, including smooth muscle of the vascular system. Therapy with carboprost should be administered cautiously in patients with a history of cardiovascular dysfunction including a history of hypo or hypertension.

References

  1. "Product Information. Hemabate (carboprost)" Pharmacia and Upjohn, Kalamazoo, MI.
Major

Carboprost (Includes Hemabate) ↔ Hepatic Dysfunction

Severe Potential Hazard, High plausibility

Applies to: Liver Disease

The use of carboprost is contraindicated in patients with active hepatic disorders. Carboprost is metabolized by the liver. The serum concentration of carboprost may be increased and the half-life prolonged in patients with active hepatic impairment. Therapy with carboprost should be administered cautiously in patients with a history of hepatic dysfunction.

References

  1. "Product Information. Hemabate (carboprost)" Pharmacia and Upjohn, Kalamazoo, MI.
Major

Carboprost (Includes Hemabate) ↔ Pulmonary Dysfunction

Severe Potential Hazard, High plausibility

Applies to: Pulmonary Impairment

The use of carboprost may be associated with bronchospasm, decreased pulmonary blood flow, and/or increased pulmonary arterial pressure. Carboprost induces contraction of smooth muscle, including smooth muscle of the respiratory tract. Therapy with carboprost is contraindicated in patients with active pulmonary disease, and should be administered cautiously in patients with a history of asthma or other pulmonary disorders.

References

  1. "Product Information. Hemabate (carboprost)" Pharmacia and Upjohn, Kalamazoo, MI.
Major

Carboprost (Includes Hemabate) ↔ Renal Dysfunction

Severe Potential Hazard, High plausibility

Applies to: Renal Dysfunction

The use of carboprost is contraindicated in patients with uncontrolled or acute renal dysfunction. Carboprost induces contraction of smooth muscle, including smooth muscle of the vascular system. Therapy with carboprost should be administered cautiously in patients with a history of renal dysfunction.

References

  1. "Product Information. Hemabate (carboprost)" Pharmacia and Upjohn, Kalamazoo, MI.
Moderate

Carboprost (Includes Hemabate) ↔ Anemia

Moderate Potential Hazard, Moderate plausibility

Applies to: Anemia

The manufacturers recommend to use caution when prescribing carboprost therapy in patients with a history of anemia.

Moderate

Carboprost (Includes Hemabate) ↔ Diabetes

Moderate Potential Hazard, Moderate plausibility

Applies to: Diabetes Mellitus

The manufacturers recommend to use caution when prescribing carboprost therapy in patients with history of diabetes.

Moderate

Carboprost (Includes Hemabate) ↔ Epilepsy

Moderate Potential Hazard, Moderate plausibility

Applies to: Seizures

The manufacturers recommend to use caution when prescribing carboprost therapy in patients with a history of epilepsy.

Hemabate (carboprost) alcohol/food Interactions

There is 1 alcohol/food interaction with Hemabate (carboprost)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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