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Ammonium chloride Disease Interactions

There are 2 disease interactions with ammonium chloride:


Ammonium chloride (applies to ammonium chloride) liver dysfunction

Major Potential Hazard, High plausibility. Applicable conditions: Liver Disease

Ammonium undergoes hepatic biotransformation to urea. Ammonium toxicity resulting in irregular heart rate, bradycardia, arrhythmia. hyperglycemia, glucosuria, twitching, asterixis, tonic seizures, and calcium- deficient tetany have occurred in patients with hepatic impairment. Therapy with ammonium chloride should be administered cautiously in patients with compromised hepatic function.


  1. "Product Information. Ammonium Chloride (ammonium chloride)." Abbott Pharmaceutical, Abbott Park, IL.

Ammonium chloride (applies to ammonium chloride) renal dysfunction

Moderate Potential Hazard, High plausibility.

Ammonium chloride should be used cautiously and under medical supervision in patients with renal impairment as it can result in hyperchloremia and metabolic acidosis. Ammonium chloride should not be administered alone in patients with severe renal impairment experiencing metabolic alkalosis secondary to vomiting of HCl and accompanied by substantial sodium loss. Sodium chloride alone or in combination with ammonium chloride may be necessary to correct the sodium and chloride loss.


  1. "Product Information. Ammonium Chloride (ammonium chloride)." Abbott Pharmaceutical, Abbott Park, IL.

Ammonium chloride drug interactions

There are 22 drug interactions with ammonium chloride

More about ammonium chloride

Related treatment guides

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.