Ammonium chloride Disease Interactions
There are 2 disease interactions with ammonium chloride.
Ammonium chloride (applies to ammonium chloride) liver dysfunction
Major Potential Hazard, High plausibility. Applicable conditions: Liver Disease
Ammonium undergoes hepatic biotransformation to urea. Ammonium toxicity resulting in irregular heart rate, bradycardia, arrhythmia. hyperglycemia, glucosuria, twitching, asterixis, tonic seizures, and calcium- deficient tetany have occurred in patients with hepatic impairment. Therapy with ammonium chloride should be administered cautiously in patients with compromised hepatic function.
Ammonium chloride (applies to ammonium chloride) renal dysfunction
Moderate Potential Hazard, High plausibility.
Ammonium chloride should be used cautiously and under medical supervision in patients with renal impairment as it can result in hyperchloremia and metabolic acidosis. Ammonium chloride should not be administered alone in patients with severe renal impairment experiencing metabolic alkalosis secondary to vomiting of HCl and accompanied by substantial sodium loss. Sodium chloride alone or in combination with ammonium chloride may be necessary to correct the sodium and chloride loss.
Ammonium chloride drug interactions
There are 22 drug interactions with ammonium chloride.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
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