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Vorinostat (Oral)

vor-IN-oh-stat

Medically reviewed by Drugs.com. Last updated on Nov 6, 2019.

Commonly used brand name(s)

In the U.S.

  • Zolinza

Available Dosage Forms:

  • Capsule

Therapeutic Class: Antineoplastic Agent

Pharmacologic Class: Histone Deacetylase Inhibitor

Uses for vorinostat

Vorinostat is used to treat cutaneous T-cell lymphoma (CTCL), a type of cancer that affects certain white blood cells and causes lesions to develop on the skin. Vorinostat is used when your CTCL gets worse, does not go away, or comes back after you have taken other medicines.

Vorinostat interferes with the growth of the cancer cells, which are eventually destroyed by the body. Since the growth of normal body cells may also be affected by vorinostat, other unwanted effects will also occur. Some of these may be serious and must be reported to your doctor. Some unwanted effects may not be serious but may cause concern. Some of the unwanted effects do not occur until months or years after the medicine is used.

Vorinostat is available only with your doctor's prescription.

Before using vorinostat

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For vorinostat, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to vorinostat or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of vorinostat in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of vorinostat in the elderly.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking vorinostat, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using vorinostat with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Amisulpride
  • Bepridil
  • Cisapride
  • Dronedarone
  • Mesoridazine
  • Pimozide
  • Piperaquine
  • Saquinavir
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Ziprasidone

Using vorinostat with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Amiodarone
  • Anagrelide
  • Aripiprazole
  • Aripiprazole Lauroxil
  • Arsenic Trioxide
  • Buprenorphine
  • Buserelin
  • Ceritinib
  • Clarithromycin
  • Clofazimine
  • Clozapine
  • Crizotinib
  • Dabrafenib
  • Dasatinib
  • Degarelix
  • Delamanid
  • Deslorelin
  • Deutetrabenazine
  • Domperidone
  • Donepezil
  • Efavirenz
  • Encorafenib
  • Entrectinib
  • Escitalopram
  • Fingolimod
  • Fluconazole
  • Fluoxetine
  • Foscarnet
  • Glasdegib
  • Gonadorelin
  • Goserelin
  • Histrelin
  • Hydroxychloroquine
  • Hydroxyzine
  • Inotuzumab Ozogamicin
  • Ivabradine
  • Ivosidenib
  • Ketoconazole
  • Lefamulin
  • Lenvatinib
  • Leuprolide
  • Levofloxacin
  • Lofexidine
  • Macimorelin
  • Methadone
  • Metronidazole
  • Moxifloxacin
  • Nafarelin
  • Nilotinib
  • Ondansetron
  • Osimertinib
  • Panobinostat
  • Pasireotide
  • Pazopanib
  • Pimavanserin
  • Pitolisant
  • Posaconazole
  • Quetiapine
  • Ribociclib
  • Sertraline
  • Sevoflurane
  • Siponimod
  • Sotalol
  • Sulpiride
  • Tacrolimus
  • Trazodone
  • Triclabendazole
  • Triptorelin
  • Valproic Acid
  • Vandetanib
  • Vemurafenib
  • Vinflunine
  • Zuclopenthixol

Using vorinostat with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acenocoumarol
  • Dicumarol
  • Phenprocoumon
  • Warfarin

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems

The presence of other medical problems may affect the use of vorinostat. Make sure you tell your doctor if you have any other medical problems, especially:

  • Blood clots, history of or
  • Diabetes or
  • Thrombocytopenia (low number of platelets)—Use with caution. May make these conditions worse.
  • Fluid or electrolyte imbalance (eg, low potassium or magnesium in the blood) or
  • Stomach or bowel problems (eg, severe diarrhea, nausea, or vomiting)—Must be corrected or treated first before using vorinostat.
  • Liver disease—Use with caution. The effects may be increased because of the slower removal of the medicine from the body.
  • Thrombocytopenia (low number of platelets), severe—Use with caution. May increase risk for more side effects (eg, stomach or bowel bleeding) when used with other medicines.

Proper use of vorinostat

Medicines used to treat cancer are very strong and can have many side effects. Before receiving vorinostat, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

Take vorinostat only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

Vorinostat comes with a patient information leaflet. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions.

Take vorinostat with food.

Swallow the capsule whole. Do not open, crush, break, or chew it.

Be careful not to handle crushed or opened capsules. If you have contact with the powder in the capsules, wash your skin with soap and water right away.

Vorinostat sometimes causes nausea and vomiting. However, it is very important that you continue to receive the medicine, even if you begin to feel ill. Ask your doctor for ways to lessen these effects.

Drink at least 2 liters of fluids per day while you are using vorinostat. This will help prevent dehydration.

Dosing

The dose of vorinostat will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of vorinostat. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For cutaneous T-cell lymphoma:
    • For oral dosage form (capsules):
      • Adults—400 milligrams (mg) once a day. Your doctor may adjust your dose as needed and tolerated.
      • Children—Use and dose must be determined by your doctor.

Missed dose

If you miss a dose of vorinostat, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions while using vorinostat

It is very important that your doctor check your progress at regular visits to make sure vorinostat is working properly. Blood and urine tests will be needed to check for unwanted effects. .

Using vorinostat while you are pregnant can harm your unborn baby. It may also cause birth defects if the father is using it when his sexual partner becomes pregnant. Female patients should use effective birth control during treatment with vorinostat and for at least 6 months after the last dose. Male patients who have female partners should use effective birth control during treatment with vorinostat and for at least 3 months after the last dose. If you think you have become pregnant while using the medicine, tell your doctor right away.

Your doctor will give you a pregnancy test within 7 days before you use vorinostat to make sure you are not pregnant.

Vorinostat may increase your risk of developing blood clots. Check with your doctor right away if you have swelling and pain in your arms, legs, or stomach, chest pain, trouble breathing, loss of sensation, confusion, or problems with muscle control or speech.

Vorinostat can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:

  • If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.
  • Check with your doctor immediately if you notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin.
  • Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done.
  • Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.
  • Be careful not to cut yourself when you are using sharp objects, such as a safety razor or fingernail or toenail cutters.
  • Avoid contact sports or other situations where bruising or injury could occur.

Vorinostat may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests, check with your doctor.

Before you have any medical tests, tell the medical doctor in charge that you are using vorinostat. The results of some tests may be affected by vorinostat.

Check with your doctor right away if you have severe diarrhea, nausea, or vomiting. You may also receive medicines to help prevent these symptoms.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Vorinostat side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  • Anxiety
  • black, tarry stools
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine or stools
  • body aches or pain
  • chest pain
  • chills
  • confusion
  • cough
  • decreased urine
  • diarrhea
  • dizziness or lightheadedness
  • dry mouth
  • ear congestion
  • fainting
  • fast or irregular heartbeat
  • fever
  • headache
  • increased thirst
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  • loss of appetite
  • loss of voice
  • lower back or side pain
  • mood changes
  • muscle pain or cramps
  • nasal congestion
  • nausea
  • no blood pressure
  • no breathing
  • no pulse
  • numbness or tingling in the face, lips, arms, hands, feet, or legs
  • pain, redness, or swelling in the arm or leg
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • rapid weight gain
  • runny nose
  • seizures
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen glands
  • trouble speaking, thinking, or walking
  • troubled breathing
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
  • vomiting

Less common

  • Persistent non-healing sore
  • pink growth
  • reddish patch or irritated area
  • shiny bump
  • white, yellow, or waxy scar-like area

Rare

  • Chest discomfort
  • general feeling of illness
  • hoarseness
  • indigestion
  • pain or discomfort in the arms, jaw, back, or neck
  • rapid, shallow breathing
  • severe nausea or vomiting
  • sneezing
  • stomach pain
  • sweating
  • tightness in the chest
  • vomiting of blood or material that looks like coffee grounds
  • yellow skin and eyes

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Change in taste
  • cracks in the skin
  • difficulty having a bowel movement
  • hair loss or thinning of the hair
  • itching skin
  • lack or loss of strength
  • loss of heat from the body
  • loss of taste
  • muscle spasm
  • red, swollen skin
  • scaly skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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