Generic Name: dabrafenib (Oral route)
Medically reviewed by Drugs.com. Last updated on Jan 20, 2020.
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Pharmacologic Class: BRAF Inhibitor
Uses for Tafinlar
Dabrafenib is used alone or in combination with trametinib to treat melanoma (skin cancer) that has spread or that cannot be removed by surgery. It is also used together with trametinib to help prevent melanoma from coming back after surgery. It is only used if the melanoma cells have the BRAF V600E or V600K mutations. Dabrafenib is also used together with trametinib to treat non-small cell lung cancer (NSCLC) that has spread and anaplastic thyroid cancer (ATC) that has spread and has no satisfactory treatment options. It is only used if the NSCLC cells and ATC cells have the BRAF V600E mutation. Your doctor will use a special test to look for these mutations. Dabrafenib belongs to the group of medicines, called antineoplastics (cancer medicines).
This medicine is available only with your doctor's prescription.
Before using Tafinlar
Appropriate studies have not been performed on the relationship of age to the effects of dabrafenib in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of dabrafenib in the elderly.
Interactions with medicines
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Abiraterone Acetate
- Aripiprazole Lauroxil
- Arsenic Trioxide
- Ethinyl Estradiol
- Inotuzumab Ozogamicin
- Sodium Phosphate
- Sodium Phosphate, Dibasic
- Sodium Phosphate, Monobasic
Interactions with food/tobacco/alcohol
Other medical problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Dehydration or
- Hypotension (low blood pressure) or
- Kidney failure—Use with caution. May cause side effects to become worse.
- Diabetes or
- Eye problem (eg, iritis, iridocyclitis, uveitis) or
- Heart disease or
- Hyperglycemia (high blood sugar)—Use with caution. May make these conditions worse.
- Glucose-6-phosphate dehydrogenase (G6PD) deficiency (a hereditary metabolic disorder affecting red blood cells)—May cause hemolytic anemia (blood disorder) in patients with this condition.
- Liver disease, moderate to severe—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
Proper use of Tafinlar
Medicines used to treat cancer are very strong and can have many side effects. Before using this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.
This medicine usually comes with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.
Take this medicine at least 1 hour before or 2 hours after a meal.
Swallow the capsule whole. Do not open, crush, or break it.
- For oral dosage form (capsules):
- For melanoma (skin cancer), non-small cell lung cancer, and anaplastic thyroid cancer:
- Adults—150 milligrams (mg) 2 times a day, taken 12 hours apart. Your doctor may adjust your dose as needed and tolerated.
- Children—Use and dose must be determined by your doctor.
- For melanoma (skin cancer), non-small cell lung cancer, and anaplastic thyroid cancer:
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
If you miss a dose and it is less than 6 hours until your next regular dose, skip the missed dose and go back to your regular dosing schedule. If you miss a dose and it is more than 6 hours until your next dose, take it as soon as possible and go back to your regular dosing schedule.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Precautions while using Tafinlar
It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.
Using this medicine while you are pregnant can harm your unborn baby. Birth control pills may not work as well to prevent pregnancy when used with this medicine. Use another form of birth control (eg, condoms, diaphragms, contraceptive foams or jellies) along with your pills. Use an effective form of birth control during treatment with this medicine and for at least 2 weeks after the last dose. If you think you have become pregnant while using the medicine, tell your doctor right away.
This medicine may cause fertility (ability to have children) problems in men and women. Talk to your doctor before using this medicine if you plan to have children.
This medicine may increase your risk of having cutaneous squamous cell carcinoma (cuSCC) or other skin cancers. Check with your doctor right away if you develop any skin changes, including a new wart, change in size or color of a mole, or a skin sore or reddish bump that does not heal. Your doctor may want your skin be checked for new skin lesions before treatment, during treatment, and for up to 6 months after the last dose.
This medicine may cause hemorrhage (severe bleeding) in the stomach and bowel areas or in the brain. Call your doctor right away if you have any unusual or unexplained bleeding.
Dabrafenib may cause heart problems. Check with your doctor right away if you have chest discomfort or pain, dizziness or faintness, fast, irregular, or pounding heartbeat, swelling of the feet or lower legs, trouble with breathing, or unusual tiredness or weakness.
Check with your doctor right away if eye pain or a change in vision occurs during treatment. This could be a sign of a serious eye problem. Your doctor may want your eyes be checked by an ophthalmologist (eye doctor).
This medicine may cause fever, including severe fever that sometimes happens with low blood pressure, chills, dehydration, or kidney problems. Check with your doctor right away if you have a fever while using this medicine.
Check with your doctor right away if you have a severe skin rash, acne, or redness, swelling, peeling, or tenderness of the hands or feet. These may be symptoms of a serious skin problem.
This medicine may affect your blood sugar levels. Check with your doctor right away if you have increased thirst or increased urination. If you notice a change in the results of your urine or blood sugar tests, or if you have any questions, check with your doctor.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Tafinlar side effects
Check with your doctor immediately if any of the following side effects occur:
- Bleeding gums
- bloody or cloudy urine
- blurred vision
- coughing up blood
- difficulty in breathing or swallowing
- dry mouth
- flushed, dry skin
- fruit-like breath odor
- greatly decreased frequency of urination or amount of urine
- increased hunger
- increased thirst
- increased urination
- lump or growth on the skin
- prolonged bleeding from cuts
- red or black, tarry stools
- red or dark brown urine
- redness, swelling, or pain of the skin
- scaling of the skin on the hands and feet
- skin blisters
- skin rash
- stomach pain
- swelling of the feet or lower legs
- tingling of the hands and feet
- ulceration of the skin
- unable to move
- unexplained weight loss
- unusual tiredness or weakness
- Blurred vision or other change in vision
- change in color vision
- difficulty seeing at night
- eye pain
- increased sensitivity of the eyes to sunlight
- redness of the eye
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Back pain
- difficulty having a bowel movement
- fast heartbeat
- hair loss or thinning of the hair
- loss of appetite
- muscle ache, pain, or stiffness
- pain in the joints
- pains in the stomach, side, or abdomen, possibly radiating to the back
- sore throat
- stuffy or runny nose
- yellow eyes or skin
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More about Tafinlar (dabrafenib)
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- Drug class: multikinase inhibitors
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