Medically reviewed by Drugs.com. Last updated on May 24, 2019.
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
- Capsule, Liquid Filled
Therapeutic Class: Cardiovascular Agent
Uses for tafamidis
Tafamidis is used to treat cardiomyopathy (enlarged and thickened heart muscle) of wild type or hereditary transthyretin-mediated amyloidosis (ATTR-CM) in adults to reduce death and hospitalization related to heart problems.
Tafamidis is available only with your doctor's prescription.
Before using tafamidis
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For tafamidis, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to tafamidis or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of tafamidis in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of tafamidis in the elderly.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Interactions with food/tobacco/alcohol
Proper use of tafamidis
Take tafamidis only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.
Tafamidis should come with a patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions.
Swallow the capsule whole. Do not cut, crush, or chew it.
Use only the brand of tafamidis that your doctor prescribed. Vyndamax™ and Vyndaqel® have different dosage strengths.
The dose of tafamidis will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of tafamidis. If your dose is different, do not change it unless your doctor tells you to do so.
- For oral dosage form (capsules):
- For cardiomyopathy:
- Vyndamax™: 61 milligrams (mg) (1 capsule) once a day.
- Vyndaqel®: 80 mg (four 20 mg capsules) once a day.
- Children—Use and dose must be determined by your doctor.
- For cardiomyopathy:
If you miss a dose of tafamidis, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Precautions while using tafamidis
It is very important that your doctor check your progress at regular visits to make sure that tafamidis is working properly and to check for unwanted effects.
Using tafamidis while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant during treatment with tafamidis. If you think you have become pregnant while using tafamidis, tell your doctor right away.
Patients who use tafamidis may register for the Transthyretin Amyloidosis Outcome Survey (THAOS), which may be used to inform and educate patients and healthcare professionals about the disease and its management. This may involve long-term follow-up.
Tafamidis side effects
Check with your doctor immediately if any of the following side effects occur:
Incidence not known
- difficulty swallowing
- fast heartbeat
- hives, itching, skin rash
- puffiness or swelling of the eyelids or around the eyes, face, lips or, tongue
- tightness in chest
- unusual tiredness or weakness
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