Medically reviewed by Drugs.com. Last updated on Nov 15, 2019.
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Sclerosing Agent
Uses for polidocanol
Polidocanol injection is used to treat small varicose veins of the lower legs. Polidocanol is also used to treat incompetent great saphenous veins, accessory saphenous veins, and visible varicose veins above and below the knees. It is a type of medicine called a sclerosing agent.
Polidocanol is to be given only by or under the direct supervision of your doctor.
Before using polidocanol
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For polidocanol, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to polidocanol or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of polidocanol injection in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of polidocanol injection in the elderly.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Interactions with food/tobacco/alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other medical problems
The presence of other medical problems may affect the use of polidocanol. Make sure you tell your doctor if you have any other medical problems, especially:
- Blood clots or
- Blood clotting disorders, acute—Should not be used in patients with these conditions.
- Blood clotting problems (eg, deep vein thrombosis, pulmonary embolism), history of or
- Major surgery, recent (within 3 months) or
- Prolonged immobilization—May increase risk for blood clotting problems.
- Blood vessel disease (eg, peripheral arteriosclerosis, thromboangiitis obliterans)—May increase risk for tissue ischemia.
Proper use of polidocanol
A nurse or other trained health professional will give you polidocanol in a hospital. It is given through a needle placed into one of your veins.
Precautions while using polidocanol
It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.
Polidocanol may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Call your doctor or nurse right away if you have a rash, itching, hoarseness, trouble with breathing or swallowing, or any swelling of your hands, face, or mouth after receiving polidocanol.
Wear compression stockings or a support hose on the treated leg(s) continuously for 2 to 3 days or for 5 to 7 days, and for 2 to 3 weeks during daytime. This would help prevent formation of blood clots.
It is recommended that you walk for 10 to 20 minutes for Varithena™ or 15 to 20 minutes for Asclera® immediately after the treatment and daily for the next few days, unless your doctor tells you otherwise.
Polidocanol may cause a permanent depression (necrosis) under the skin at the injection site. Contact your doctor right away if you notice any of these side effects at the injection site: depressed or indented skin, blue-green to black skin discoloration, or pain, redness, or sloughing (peeling) of the skin.
Avoid heavy exercise, sunbathing, long plane flights, and hot baths or sauna for 2 to 3 days after receiving polidocanol.
Polidocanol side effects
Check with your doctor or nurse immediately if any of the following side effects occur:
- Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
- collection of blood under the skin of the injection site
- deep, dark purple bruise at the injection site
Incidence not known
- blue-green to black skin discoloration
- blurred vision
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- chest pain
- darkening of the skin
- difficult or labored breathing
- difficulty with swallowing
- dizziness or lightheadedness
- fast, irregular, pounding, or racing heartbeat or pulse
- inability to speak
- increased hair growth in the treatment area
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
- loss of consciousness
- nerve injury
- no blood pressure or pulse
- noisy breathing
- pain, redness, or sloughing of the skin at the injection site
- pain, redness, or swelling in the arm or leg
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- severe or sudden headache
- skin rash
- slurred speech
- sores, welts, or blisters
- stopping of the heart
- temporary blindness
- tightness in the chest
- troubled breathing
- unusual tiredness or weakness
- weakness in the arm or leg on one side of the body, sudden and severe
Get emergency help immediately if any of the following symptoms of overdose occur:
Symptoms of overdose
- Break in the skin, especially associated with blue-black discoloration, swelling, or drainage of fluid
Incidence not known
- feeling of warmth
- redness of the face, neck, arms, and occasionally, upper chest
- sudden sweating
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- Drug class: sclerosing agents