Generic Name: naphazoline (naf-AZ-oh-leen) (Ophthalmic route)
Medically reviewed by Drugs.com. Last updated on Aug 12, 2020.
The Ocu-Zoline brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.
Commonly used brand name(s)
In the U.S.
- Clear Eyes
Available Dosage Forms:
Therapeutic Class: Decongestant
Pharmacologic Class: Sympathomimetic
Chemical Class: Imidazoline
Uses for Ocu-Zoline
Naphazoline is used to relieve redness due to minor eye irritations, such as those caused by colds, dust, wind, smog, pollen, swimming, or wearing contact lenses.
Some of these preparations are available only with your doctor's prescription.
Before using Ocu-Zoline
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Use by infants and children is not recommended, since they are especially sensitive to the effects of naphazoline.
Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of naphazoline in the elderly with use in other age groups.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Iobenguane I 131
Interactions with food/tobacco/alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other medical problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Type 2 diabetes mellitus or
- Heart disease or
- High blood pressure or
- Overactive thyroid—Use of ophthalmic naphazoline may make the condition worse
- Eye disease, infection, or injury—The symptoms of the condition may be confused with possible side effects of ophthalmic naphazoline
Proper use of Ocu-Zoline
This section provides information on the proper use of a number of products that contain naphazoline. It may not be specific to Ocu-Zoline. Please read with care.
Do not use naphazoline ophthalmic solution if it becomes cloudy or changes color.
Naphazoline should not be used in infants and children . It may cause severe slowing down of the central nervous system (CNS), which may lead to unconsciousness. It may also cause a severe decrease in body temperature.
Use this medicine only as directed. Do not use more of it, do not use it more often, and do not use it for more than 72 hours, unless otherwise directed by your doctor. To do so may make your eye redness and irritation worse and may also increase the chance of side effects.
- First, wash your hands. With the middle finger, apply pressure to the inside corner of the eye (and continue to apply pressure for 1 or 2 minutes after the medicine has been placed in the eye). Tilt the head back and with the index finger of the same hand, pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close the eyes. Do not blink. Keep the eyes closed for 1 or 2 minutes to allow the medicine to be absorbed.
- To keep the medicine as germ-free as possible, do not touch the applicator tip to any surface (including the eye). Also, keep the container tightly closed.
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For ophthalmic solution (eye drop) dosage form:
- For eye redness:
- Adults—Use one drop not more often than every four hours.
- Children—Use is not recommended.
- For eye redness:
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Precautions while using Ocu-Zoline
If eye pain or change in vision occurs or if redness or irritation of the eye continues, gets worse, or lasts for more than 72 hours, stop using the medicine and check with your doctor.
Ocu-Zoline side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
With overuse or long-term use
- Increase in eye irritation
Symptoms of too much medicine being absorbed into the body
- increased sweating
Symptoms of overdose
- Decrease in body temperature
- slow heartbeat
- weakness (severe)
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common or rare
- Blurred vision
- large pupils
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
More about Ocu-Zoline (naphazoline ophthalmic)
- Side Effects
- Drug Interactions
- Drug class: ophthalmic antihistamines and decongestants
- FDA Alerts (1)
Related treatment guides
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.