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Luspatercept-aamt (Injection)

lus-PAT-er-sept - aamt

Medically reviewed by Drugs.com. Last updated on Jul 9, 2019.

Uses for luspatercept-aamt

Luspatercept-aamt injection is used to treat anemia in patients with beta thalassemia who need regular red blood cell (RBC) transfusions.

Luspatercept-aamt is to be given only by or under the immediate supervision of your doctor.

Before using luspatercept-aamt

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For luspatercept-aamt, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to luspatercept-aamt or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of luspatercept-aamt injection in the pediatric population. Use in children is not recommended.

Geriatric

Appropriate studies have not been performed on the relationship of age to the effects of luspatercept-aamt injection in the geriatric population.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems

The presence of other medical problems may affect the use of luspatercept-aamt. Make sure you tell your doctor if you have any other medical problems, especially:

  • Blood clots, history of or
  • Hypertension (high blood pressure)—Use with caution. May make these conditions worse.
  • Smoking or
  • Splenectomy (surgery to remove the spleen), history of—May increase risk for more serious side effects.

Proper use of luspatercept-aamt

A doctor or other trained health professional will give you luspatercept-aamt in a hospital. It is given as a shot under your skin once every 3 weeks.

Missed dose

Call your doctor or pharmacist for instructions.

Precautions while using luspatercept-aamt

It is very important that your doctor check your progress closely at regular visits to see if the medicine is working properly. Blood tests may be needed to check for any unwanted effects.

Using luspatercept-aamt while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant during treatment with luspatercept-aamt and for at least 3 months after the last dose. If you think you have become pregnant while using luspatercept-aamt, tell your doctor right away.

Luspatercept-aamt may increase your risk of having blood clots (eg, deep vein thrombosis, ischemic strokes, portal vein thrombosis, pulmonary embolus). Check with your doctor right away if you have pain in the chest, groin, or legs, especially the calves, trouble breathing, severe, sudden headache, slurred speech, sudden loss of coordination, sudden, severe weakness or numbness in arm or leg, or vision changes.

Call your doctor right away if you have blurred vision, dizziness, nervousness, headache, pounding in the ears, or slow or fast heartbeat. These may be symptoms of high blood pressure.

Luspatercept-aamt side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  • Blurred vision
  • bone pain
  • dizziness
  • headache
  • nervousness
  • pounding in the ears
  • slow or fast heartbeat

Less common

  • Chest pain or tightness
  • fever
  • hives, itching, or skin rash
  • hoarseness
  • inability to speak
  • irritation
  • joint pain, stiffness, or swelling
  • lightheadedness or fainting
  • pain, redness, or swelling in the arm or leg
  • redness of the skin
  • seizures
  • severe or sudden headache
  • slurred speech
  • swelling of the eyelids, face, lips, hands, or feet
  • temporary blindness
  • troubled breathing or swallowing
  • weakness in the arm or leg on one side of the body, sudden and severe

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Body aches or pain
  • chills
  • cough
  • diarrhea
  • difficulty in moving
  • ear congestion
  • general feeling of discomfort or illness
  • loss of appetite
  • loss of voice
  • lower back, side, or stomach pain
  • muscle pain or stiffness
  • nausea or vomiting
  • runny or stuffy nose
  • shivering
  • sneezing
  • sore throat
  • stomach pain
  • sweating
  • trouble sleeping
  • unusual tiredness or weakness

Less common

  • Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • feeling of constant movement of self or surroundings
  • sensation of spinning

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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