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Duraprep (Topical application)

Generic name: iodine povacrylex and isopropyl alcoholEYE-oh-dine-poe-va-KRYE-lex, eye-soe-PROE-pil-AL-ka-hol ]

Medically reviewed by Last updated on Oct 28, 2023.

Uses for Duraprep

Iodine povacrylex and isopropyl alcohol topical is used to clean the skin before surgery and helps reduce bacteria that may cause skin infection. It works by killing or preventing the growth of bacteria on the skin.

This medicine is available without a prescription.

Before using Duraprep

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Use in children younger than 2 months of age is not recommended because of the risk of serious skin irritation and hypothyroidism (low thyroid levels).


No information is available on the relationship of age to the effects of Duraprep™ in geriatric patients.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Proper use of Duraprep

You may be instructed to use this medicine at home. It is very important that you use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause irritation of the skin.

Duraprep™ should only be used on the skin. Do not use on open wounds or as a general skin cleanser. Do not get it in the eyes, ears, mouth, or nose. If it does get on these areas, rinse it off right away.

Follow your doctor's instructions about how to clean and care for your skin before and after you use this medicine. Make sure you understand all of the directions, and ask questions if you find something is not clear.

Duraprep™ is flammable. Keep it away from fire or flame. Use in a well-ventilated area. Do not microwave or heat the applicator.

To apply:


Ask your healthcare professional how you should dispose of any medicine you do not use.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Duraprep™ will not dissolve in water and may stain. Avoid contact with reusable items.

Precautions while using Duraprep

Call your doctor if you have skin irritation that does not go away, including redness, itching, or burning in the area where you used this medicine.

Side Effects of Duraprep

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Commonly used brand name(s)

In the U.S.

Available Dosage Forms:

Therapeutic Class: Antibacterial

More about DuraPrep (iodine povacrylex / isopropyl alcohol topical)

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.