anagrelide (Oral route)
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Platelet Reducing Agent
Uses For anagrelide
Anagrelide is used to decrease the risk of blood clots in patients who have thrombocythemia (too many platelets in the blood). It works to decrease production of platelets in the body.
anagrelide is available only with your doctor's prescription.
Before Using anagrelide
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For anagrelide, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to anagrelide or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of anagrelide in children.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of anagrelide in the elderly.
|All Trimesters||C||Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking anagrelide, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using anagrelide with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using anagrelide with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Alipogene Tiparvovec
- Amtolmetin Guacil
- Arsenic Trioxide
- Choline Salicylate
- Dabigatran Etexilate
- Ethinyl Estradiol
- Flufenamic Acid
- Mefenamic Acid
- Niflumic Acid
- Nimesulide Beta Cyclodextrin
- Peginterferon Alfa-2b
- Protein C
- Salicylic Acid
- Sodium Phosphate
- Sodium Phosphate, Dibasic
- Sodium Phosphate, Monobasic
- Sodium Salicylate
- Tiaprofenic Acid
- Tolfenamic Acid
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Other Medical Problems
The presence of other medical problems may affect the use of anagrelide. Make sure you tell your doctor if you have any other medical problems, especially:
- Bleeding problems or
- Congestive heart failure, history of or
- Heart disease, history of or
- Heart rhythm problems, history of or
- Hypotension (low blood pressure) or
- Kidney disease or
- Lung disease (eg, interstitial lung disease), history of—Use with caution. May make these conditions worse.
- Liver disease, mild or moderate—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
- Heart rhythm problem (eg, congenital long QT syndrome, QT prolongation) or
- Hypokalemia (low potassium in the blood) or
- Liver disease, severe—Should not be used in patients with this condition.
Proper Use of anagrelide
Take anagrelide exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance for side effects.
You may take anagrelide with or without food.
The dose of anagrelide will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of anagrelide. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For oral dosage form (capsules):
- For thrombocythemia:
- Adults—At first, 0.5 milligram (mg) four times a day or 1 mg two times a day, taken for at least 1 week. Your doctor may adjust your dose if needed.
- Children—At first, 0.5 mg per day. Your doctor may adjust your dose if needed.
- For thrombocythemia:
If you miss a dose of anagrelide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Precautions While Using anagrelide
It is very important that your doctor check the progress of you or your child at regular visits to make sure that anagrelide is working properly. Blood tests are needed to check for unwanted effects. You will also need to have an ECG test (electrocardiogram) to check your heart rhythm.
anagrelide may cause unwanted effects on the heart. Check with your doctor right away if you or your child have chest pain, tightness, or discomfort, decreased urine output, dilated neck veins, extreme fatigue, a fast, pounding, or uneven heartbeat or pulse, pain or discomfort in the arms, jaw, back or neck, nausea or vomiting, sweating, swelling of the face, fingers, feet, or lower legs, trouble breathing, or weight gain. These could be symptoms of a serious heart problem.
anagrelide may also increase your risk of bleeding. Check with your doctor immediately if you or your child notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin.
Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.
Check with your doctor right away if you or your child have breathing problems, a cough, a fever, a fast heartbeat, or shortness of breath. These could be symptoms of a serious lung problem.
Do not stop using anagrelide suddenly without checking first with your doctor. You may need to slowly decrease your dose before stopping it completely. To do so will cause the platelet level in your blood to increase quickly.
Do not take aspirin or aspirin-containing products since they may also affect your platelets. Do not take any other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
anagrelide Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:More common
- Bloating or swelling of the face, arms, hands, lower legs, or feet
- body aches or pain
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- chest pain
- difficult or labored breathing
- dryness or soreness of the throat
- fast, irregular, pounding, or racing heartbeat or pulse
- rapid weight gain
- runny nose
- tender, swollen glands in the neck
- tightness in the chest
- trouble with swallowing
- voice changes
- blurred vision
- burning while urinating
- cold sweats
- decreased urine output
- difficult or painful urination
- dilated neck veins
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- extreme fatigue
- general feeling of discomfort or illness
- irregular breathing
- joint pain
- large, flat, blue, or purplish patches in the skin
- loss of appetite
- muscle aches and pains
- nausea or vomiting
- noisy breathing
- pale skin
- redness of the face, neck, arms, and occasionally, upper chest
- severe pain or pressure in the chest or the jaw, neck, back, or arms
- sudden severe headache or weakness
- swollen, painful, or tender lymph glands in the neck, armpit, or groin
- trouble sleeping
- troubled breathing with exertion
- unusual bleeding or bruising
- unusual tiredness or weakness
- vomiting of blood or material that looks like coffee grounds
- weight gain
- Abdominal or stomach pain or tenderness
- clay colored stools
- dark urine
- decreased appetite
- dry cough
- general feeling of tiredness or weakness
- rapid breathing
- skin rash or itching
- yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Acid or sour stomach
- back pain
- excess air or gas in the stomach or intestines
- full feeling
- general feeling of discomfort or illness
- hives or welts
- lack or loss of strength
- passing gas
- stomach discomfort, upset, or pain
- Burning feeling in the chest or stomach
- change in vision
- continuing ringing or buzzing or other unexplained noise in the ears
- difficulty with moving
- double vision
- hair loss or thinning of the hair
- hearing loss
- impaired vision
- increased sensitivity of the skin to sunlight
- leg cramps
- loss of memory
- muscle pain or stiffness
- problems with memory
- redness or other discoloration of the skin
- seeing double
- severe sunburn
- sleepiness or unusual drowsiness
- stuffy nose
- swelling or inflammation of the mouth
- swollen joints
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
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Other brands: Agrylin