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Polysubstance Use Disorder

Medically reviewed by Last updated on Mar 3, 2024.

Polysubstance use disorder (PUD) is a medical condition that develops from long-term use or misuse of 2 or more substances. You are not able to stop even though it causes physical or social problems. PUD includes use of a drug such as cocaine or misuse of alcohol, tobacco, or a prescription medicine such as opioids. This disorder is also called polysubstance abuse.


Call your local emergency number (911 in the US) or have someone call if:

Return to the emergency department if:

Call your doctor or therapist if:



may be offered in a hospital, outpatient facility, or drug rehabilitation center. Healthcare providers can help you make decisions about treatment programs. The goal is to help you decrease or stop taking the substances.

Safety guidelines:

Follow up with your doctor or therapist as directed:

Write down your questions so you remember to ask them during your visits.

For support and more information:

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The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.