Skip to Content




is a condition that causes your blood to clot more easily than normal. Hypercoagulation can be an acquired or inherited condition. Acquired hypercoagulation is caused by a disease or other condition. Examples include obesity, pregnancy, use of birth control pills, or cancer. Inherited coagulation is caused by genes that have been passed to you from a parent. These genes cause problems with how your blood clots. You may have no signs or symptoms of hypercoagulation until you get a blood clot.

Risks of hypercoagulation:

Hypercoagulation may cause blood clots to form anywhere in your body. Some of these conditions may become life-threatening. You may be at risk for any of the following:

  • A deep venous thrombosis (DVT) happens when a clot forms in a deep vein, such as veins in your legs or pelvis. This blocks blood flow to parts of your leg and foot. A DVT may travel to other parts of your body and block blood flow.
  • A stroke happens when a blood clot blocks blood flow to your brain.
  • A heart attack happens when a blood clot blocks blood flow to your heart.
  • A pulmonary embolism (PE) happens when a blood clot blocks blood flow to your lungs.
  • Problems with pregnancy , such as clots in the placenta, may happen. The placenta provides oxygen and nutrition to your unborn baby. The placenta also removes waste products from the baby. Clots in the placenta can reduce blood flow to the baby. This may cause a miscarriage or problems with the baby's development.
  • Peripheral artery disease (PAD) happens when blood flow to the legs and pelvis decreases. It is caused by tiny clots in the blood vessels in your pelvis or legs.
  • Kidney failure can happen when 1 or more blood clots block blood flow to your kidneys. This prevents the kidneys from removing waste and fluid from your body.

Call 911 or have someone else call for any of the following:

  • You have any of the following signs of a stroke:
    • Numbness or drooping on one side of your face
    • Weakness in an arm or leg
    • Confusion or difficulty speaking
    • Dizziness, a severe headache, or vision loss
  • You have any of the following signs of a heart attack:
    • Squeezing, pressure, or pain in your chest that lasts longer than 5 minutes or returns
    • Discomfort or pain in your back, neck, jaw, stomach, or arm
    • Trouble breathing
    • Nausea or vomiting
    • Lightheadedness or a sudden cold sweat, especially with chest pain or trouble breathing

Seek care immediately if:

  • Your arm or leg feels warm, tender, and painful. It may look swollen and red.

Contact your healthcare provider if:

  • You have a fever or chills.
  • You have hard, bulging veins on your arms or legs.
  • You have skin changes, such as wounds or reddish blue spots.
  • You have questions or concerns about your condition or care.

Treatment for hypercoagulation

depends on the cause of your hypercoagulation. The goal of treatment is to prevent a clot from forming. Conditions such as diabetes or heart disease may need to be treated. Medicines that cause blood clots may be stopped or changed. You may need any of the following:

  • Blood thinners help prevent blood clots. Examples of blood thinners include heparin and warfarin. Clots can cause strokes, heart attacks, and death. The following are general safety guidelines to follow while you are taking a blood thinner:
    • Watch for bleeding and bruising while you take blood thinners. Watch for bleeding from your gums or nose. Watch for blood in your urine and bowel movements. Use a soft washcloth on your skin, and a soft toothbrush to brush your teeth. This can keep your skin and gums from bleeding. If you shave, use an electric shaver. Do not play contact sports.
    • Tell your dentist and other healthcare providers that you take anticoagulants. Wear a bracelet or necklace that says you take this medicine.
    • Do not start or stop any medicines unless your healthcare provider tells you to. Many medicines cannot be used with blood thinners.
    • Tell your healthcare provider right away if you forget to take the medicine, or if you take too much.
    • Warfarin is a blood thinner that you may need to take. The following are things you should be aware of if you take warfarin.
      • Foods and medicines can affect the amount of warfarin in your blood. Do not make major changes to your diet while you take warfarin. Warfarin works best when you eat about the same amount of vitamin K every day. Vitamin K is found in green leafy vegetables and certain other foods. Ask for more information about what to eat when you are taking warfarin.
      • You will need to see your healthcare provider for follow-up visits when you are on warfarin. You will need regular blood tests. These tests are used to decide how much medicine you need.
  • Antiplatelets , such as aspirin, help prevent blood clots. Take your antiplatelet medicine exactly as directed. These medicines make it more likely for you to bleed or bruise. If you are told to take aspirin, do not take acetaminophen or ibuprofen instead.
  • Take your medicine as directed. Call your healthcare provider if you think your medicine is not helping or if you have side effects. Tell him if you are allergic to any medicine. Keep a list of the medicines, vitamins, and herbs you take. Include the amounts, and when and why you take them. Bring the list or the pill bottles to follow-up visits. Carry your medicine list with you in case of an emergency.

Prevent a blood clot:

  • Change your body position often during travel and at work. If you travel by airplane, get up and walk around once every hour. Move and stretch in your seat several times each hour. Do leg exercises at work and during travel to increase blood flow through your legs
    • Point your toes toward your shin. Then point them toward the ground. Do this 10 times every hour.
    • Pull each knee to your chest and hold it for 15 seconds. Then straighten your leg. Do this 10 times every hour.
  • Change your position every 2 hours in bed. If you need help to move, ask other family members to help you change your position.
  • Eat a variety of healthy foods. Healthy foods can help you manage your weight and other health problems. Examples include fruits, vegetables, whole-grain breads, low-fat dairy products, beans, lean meats, and fish. Ask if you need to be on a special diet.
  • Drink plenty of liquids. Liquids can help prevent dehydration. Ask how much liquid to drink each day and which liquids are best for you. You should drink extra liquids before plane rides and long car rides.
  • Get plenty of exercise. Talk to your healthcare provider about the best exercise plan for you. Exercise can help you lose weight, keep your heart healthy, and help manage other conditions.
  • Do not smoke. Nicotine and other chemicals in cigarettes and cigars can heart and lung damage. Ask your healthcare provider for information if you currently smoke and need help to quit. E-cigarettes or smokeless tobacco still contain nicotine. Talk to your healthcare provider before you use these products.
  • Wear pressure stockings as directed. These are tight elastic stockings that squeeze the lower part of your legs to improve circulation. This helps keep blood clots from forming. Ask your healthcare provider where to buy these products.

  • Talk to your healthcare provider before you get pregnant. You may need to take medicine to prevent blood clots during your pregnancy.

Follow up with your healthcare provider as directed:

Write down your questions so you remember to ask them during your visits.

© 2016 Truven Health Analytics Inc. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. All illustrations and images included in CareNotes® are the copyrighted property of A.D.A.M., Inc. or Truven Health Analytics.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.