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Tenecteplase

Generic Name: Tenecteplase (ten EK te plase)
Brand Name: TNKase

Medically reviewed by Drugs.com. Last updated on Mar 23, 2019.

Uses of Tenecteplase:

What do I need to tell my doctor BEFORE I take Tenecteplase?

  • If you have an allergy to tenecteplase or any other part of tenecteplase.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have any of these health problems: Aneurysm, arteriovenous malformations, bleeding problems like bleeding in the brain, brain tumor, or high blood pressure.
  • If you have had any of these health problems: Stroke; injury to the head, brain, or spine; or surgery on the brain or spine.

This is not a list of all drugs or health problems that interact with tenecteplase.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take tenecteplase with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Tenecteplase?

  • Tell all of your health care providers that you take tenecteplase. This includes your doctors, nurses, pharmacists, and dentists.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • This medicine may affect certain lab tests. Be sure your doctor and lab workers know you use tenecteplase.
  • You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
  • Very bad and sometimes deadly bleeding problems have happened with tenecteplase. Talk with the doctor.
  • Use care to prevent injury and avoid falls or crashes.
  • People with certain heart problems may have a raised chance of a blood clot with tenecteplase. If you have questions about whether you may have a raised chance of a blood clot, talk with your doctor.
  • If you are 65 or older, use tenecteplase with care. You could have more side effects.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using tenecteplase while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Tenecteplase) best taken?

Use tenecteplase as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given as a shot into a vein.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
  • Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
  • Feeling confused.
  • A heartbeat that does not feel normal.
  • Slow heartbeat.
  • Rarely, a health problem called cholesterol embolism has happened with drugs like this one. This problem has also happened with some blood vessel procedures. Sometimes, this can be deadly. Call your doctor right away if you have a change in color of the skin to bluish, black, or purple. Call your doctor right away if you have a change in how much urine is passed; severe headache or dizziness; passing out; chest pain or pressure; change in eyesight; muscle pain or dark urine; or severe stomach pain, back pain, upset stomach, or throwing up.

What are some other side effects of Tenecteplase?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if you have any side effects that bother you or do not go away.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Tenecteplase?

  • If you need to store tenecteplase at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about tenecteplase, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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