Generic Name: Enasidenib (en a SID a nib)
Brand Name: IDHIFA
Medically reviewed by Drugs.com. Last updated on May 24, 2020.
- A health problem called differentiation syndrome has happened. This may cause organ problems and can be deadly if not treated. Call your doctor right away if you have bone pain, cough, fever, shortness of breath or other breathing problems, sudden weight gain, swelling in the arms or legs, or swollen gland. Call your doctor right away if you have signs of liver problems like dark urine or yellow skin or eyes; signs of kidney problems like unable to pass urine, change in amount of urine passed, or blood in the urine; or signs of low blood pressure like dizziness or passing out.
Uses of IDHIFA:
- It is used to treat a type of leukemia.
What do I need to tell my doctor BEFORE I take IDHIFA?
- If you are allergic to IDHIFA (enasidenib); any part of IDHIFA (enasidenib); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
- If you are breast-feeding. Do not breast-feed while you take IDHIFA (enasidenib) or for 2 months after your last dose.
This medicine may interact with other drugs or health problems.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take IDHIFA (enasidenib) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take IDHIFA?
- Tell all of your health care providers that you take IDHIFA (enasidenib). This includes your doctors, nurses, pharmacists, and dentists.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- This medicine may affect fertility. Fertility problems may lead to not being able to get pregnant or father a child.
- This medicine may cause harm to an unborn baby. A pregnancy test will be done before you start IDHIFA (enasidenib) to show that you are NOT pregnant.
- Women must use birth control while taking IDHIFA (enasidenib) and for some time after the last dose. Ask your doctor how long to use birth control. If you get pregnant, call your doctor right away.
- Men with a partner who may get pregnant must use birth control while taking IDHIFA (enasidenib) and for some time after the last dose. Ask your doctor how long to use birth control. If your partner gets pregnant, call the doctor right away.
How is this medicine (IDHIFA) best taken?
Use IDHIFA (enasidenib) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Take with or without food.
- Swallow whole with a full glass of water.
- Do not chew, break, or crush.
- Take IDHIFA (enasidenib) at the same time of day.
- Keep taking IDHIFA (enasidenib) as you have been told by your doctor or other health care provider, even if you feel well.
- Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.
- If you throw up right after taking IDHIFA (enasidenib), take 1 more dose as soon as you can on the same day. Then go back to your normal time the next day.
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it on the same day you missed the dose.
- If you do not think about the missed dose until the next day, skip the missed dose and go back to your normal time.
- Do not take 2 doses on the same day.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, seizures, not hungry, or very bad upset stomach or throwing up.
- Yellow skin or eyes.
- Patients with cancer who take IDHIFA (enasidenib) may be at a greater risk of getting a severe health problem called tumor lysis syndrome (TLS).This may lead to death. Call your doctor right away if you have a fast or abnormal heartbeat; any passing out; trouble passing urine; muscle weakness or cramps; upset stomach, throwing up, diarrhea, or not able to eat; or feel sluggish.
What are some other side effects of IDHIFA?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Change in taste.
- Diarrhea, throwing up, upset stomach, and feeling less hungry are common with IDHIFA (enasidenib). If these happen, talk with your doctor about ways to lower these side effects. Call your doctor right away if any of these effects bother you, do not get better, or get very bad.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out IDHIFA?
- Store at room temperature in a dry place. Do not store in a bathroom.
- Keep lid tightly closed.
- Store in the original container. Do not take out the antimoisture cube or packet.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time IDHIFA (enasidenib) is refilled. If you have any questions about IDHIFA (enasidenib), please talk with the doctor, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Frequently Asked Questions
- What is Idhifa used to treat?
- How does Idhifa work in acute myeloid leukemia (AML)?
- How long does it take for Idhifa to start working?
- Can Idhifa cause differentiation syndrome?
More about Idhifa (enasidenib)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Pricing & Coupons
- En Español
- Drug class: miscellaneous antineoplastics
- FDA Alerts (1)
- FDA Approval History