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Fedratinib

Generic Name: Fedratinib (fed RA ti nib)
Brand Name: Inrebic

Medically reviewed by Drugs.com. Last updated on Jun 21, 2019.

Warning

  • Severe brain or nervous system problems, like Wernicke's encephalopathy, have happened with fedratinib. Sometimes, this has been deadly. Talk with your doctor if you have low thiamine (vitamin B1) levels or poor nutrition. Tell your doctor if you have sudden weight loss or weight loss without trying. You will need to have your thiamine level checked. Call your doctor right away if you feel confused or very sleepy. Call your doctor right away if you have a change in balance, change in eyesight, trouble thinking or walking, or memory problems.

Uses of Fedratinib:

  • It is used to treat myelofibrosis.

What do I need to tell my doctor BEFORE I take Fedratinib?

  • If you have an allergy to fedratinib or any part of fedratinib.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have liver disease.
  • If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with fedratinib, like certain drugs that are used for HIV, infections, or seizures. There are many drugs that must not be taken with fedratinib.
  • If you are breast-feeding. Do not breast-feed while you take fedratinib or for 1 month after you stop fedratinib.

This is not a list of all drugs or health problems that interact with fedratinib.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take fedratinib with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Fedratinib?

  • Tell all of your health care providers that you take fedratinib. This includes your doctors, nurses, pharmacists, and dentists.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using fedratinib while you are pregnant.

How is this medicine (Fedratinib) best taken?

Use fedratinib as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take with or without food.
  • Taking fedratinib with a high-fat meal may help if you have upset stomach and throwing up.
  • Keep taking fedratinib as you have been told by your doctor or other health care provider, even if you feel well.

What do I do if I miss a dose?

  • Skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Signs of a pancreas problem (pancreatitis) like very bad stomach pain, very bad back pain, or very bad upset stomach or throwing up.
  • Signs of a urinary tract infection (UTI) like blood in the urine, burning or pain when passing urine, feeling the need to pass urine often or right away, fever, lower stomach pain, or pelvic pain.
  • Signs of low sodium levels like headache, trouble focusing, memory problems, feeling confused, weakness, seizures, or change in balance.
  • Low blood cell counts have happened with fedratinib. If blood cell counts get very low, this can lead to bleeding problems, infections, or anemia. Call your doctor right away if you have signs of infection like fever, chills, or sore throat; any unexplained bruising or bleeding; or if you feel very tired or weak.

What are some other side effects of Fedratinib?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Feeling dizzy, tired, or weak.
  • Muscle spasm.
  • Pain in arms or legs.
  • Headache.
  • Weight gain.
  • Bone pain.
  • Diarrhea, throwing up, and upset stomach are common with fedratinib. If these happen, talk with your doctor about ways to lower these side effects. Call your doctor right away if any of these effects bother you, do not go away, or get very bad.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Fedratinib?

  • Store at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time fedratinib is refilled. If you have any questions about fedratinib, please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

More about fedratinib

Consumer resources

Other brands: Inrebic

Professional resources

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