C1 Inhibitor (Recombinant)
Generic Name: C1 Inhibitor (Recombinant) (cee won in HIB i ter ree KOM be nant)
Brand Name: Ruconest
Medically reviewed on July 4, 2018
Uses of C1 Inhibitor:
- It is used to treat swelling attacks in people with hereditary angioedema (HAE).
What do I need to tell my doctor BEFORE I take C1 Inhibitor?
- If you have an allergy to C1 inhibitor or any other part of C1 inhibitor (recombinant).
- If you are allergic to rabbits.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
This medicine may interact with other drugs or health problems.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take C1 inhibitor (recombinant) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take C1 Inhibitor?
- Tell all of your health care providers that you take C1 inhibitor (recombinant). This includes your doctors, nurses, pharmacists, and dentists.
- Unsafe allergic effects may rarely happen.
- Blood clots have happened with C1 inhibitor (recombinant). The chance may be raised if you have a certain type of catheter or device in a vein or if you take certain drugs like estrogens or androgens. The chance may be raised if you have ever had heart or blood vessel disease, stroke, thick blood, or a blood clot. The chance may also be raised if you have not been able to move around for some time. Talk with your doctor.
- Talk with the doctor before you travel. You will need to bring enough of C1 inhibitor (recombinant) for use during travel.
- If your weight changes, talk with your doctor. The dose of C1 inhibitor (recombinant) may need to be changed.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using C1 inhibitor (recombinant) while you are pregnant.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
How is this medicine (C1 Inhibitor) best taken?
Use C1 inhibitor (recombinant) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- It is given as a shot into a vein.
- If you will be giving yourself the shot, your doctor or nurse will teach you how to give the shot.
- Follow how to use as you have been told by the doctor or read the package insert.
- This medicine needs to be mixed before use. Follow how to mix as you were told by the doctor.
- If stored in a refrigerator, let C1 inhibitor (recombinant) come to room temperature before mixing. Do not heat C1 inhibitor (recombinant).
- Use your dose within 8 hours after mixing.
- Do not use if the solution is cloudy, leaking, or has particles.
- Do not use if solution changes color.
- Throw away any part left over after the dose is given.
- Throw away needles in a needle/sharp disposal box. Do not reuse needles or other items. When the box is full, follow all local rules for getting rid of it. Talk with a doctor or pharmacist if you have any questions.
- Most of the time, 1 dose is enough to treat an attack. Sometimes, a second dose may be needed. Talk with the doctor to find out what to do after using a dose of C1 inhibitor (recombinant).
What do I do if I miss a dose?
- This medicine is taken on an as needed basis. Do not take more often than told by the doctor.
See also: Dosage Information (in more detail)
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
- Very bad dizziness or passing out.
- Change in color of mouth to blue.
- A fast heartbeat.
- Very bad headache.
- Call your doctor right away if you have signs of a blood clot like chest pain or pressure; coughing up blood; shortness of breath; swelling, warmth, numbness, change of color, or pain in a leg or arm; or trouble speaking or swallowing.
What are some other side effects of C1 Inhibitor?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
See also: Side effects (in more detail)
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out C1 Inhibitor?
- Store in the original container at room temperature or in a refrigerator.
- Do not freeze.
- Protect from light.
- After mixing, store in a refrigerator. Check with the doctor or pharmacist if you have questions about how long C1 inhibitor (recombinant) may be used after mixing.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about C1 inhibitor (recombinant), please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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