Carbinoxamine use while Breastfeeding

Drugs containing Carbinoxamine: Carboxine, Palgic, Arbinoxa, Rondamine, Maldec, Coldec, Karbinal ER, Histex HC, XiraHistDM, Histex PD, Show all 97 »Carbic-D, Carbodex DM Drops, Carbodec, Carboxine 12D, Pediatex 12D, X-Hist, Coldec D, Biohist LA, Norel LA, Pseudox M, Pannaz S, Mintex HC, Tri-Vent HC, Nacon, Pannaz, HistamaxD, XiraHist, Carbiset, Aridex-D Pediatric, Aridex-D, Cardec-S, Cordron-12 D, Cordron-D NR, Pediatex-D, Cordron-D, Pseudo Carb, Carboxine-D, Palgic DS, Mintex PSE, PSE Allergy, Carboxine-PSE, Hydro-Tussin CBX, Palgic-D, Mooredec, Andec, Palgic-DC, Andec-TR, Dura-Ron, Andehist, Coldec-TR, Ex-Dec-TR, Cydec, Excof, Trituss-A, DMax Pediatric, DMax Syrup, DMax Pediatric Drops, Andehist DM NR, Cordron-DM, Rondamine DM, Biodec DM, Tussafed, Dynatuss, X-Hist DM, Dacex-A, Pediox, Pediatex, Cordron NR, Ryvent, Pediatex 12, Histex CT, TriTuss-A Drops, DMax, Histex IE, Maldec-DM, Cydec-DM Syrup, PSE Allergy DM, Carb PSE 12 DM, Carboxine 12 DM, Carboxine DM, Cordron-12 DM, Pediatex 12 DM, Excof-SF, Donatussin MAX, Aridex, PSE Carb DM Drops, PSE Carbinoxamine DM, Carbofed DM Drops, Carbaxef-DM, Cydec-DM Drops, Dura-Ron DM, Decahist-DM, Pediatex-DM, Mintex DM, Pseudo Carb DM, Cordron-DM NR, Max HC

Carbinoxamine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small occasional doses of carbinoxamine are probably acceptable during breastfeeding. Larger doses or more prolonged use may cause drowsiness and other effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

There are no reports of infants breastfed during maternal therapy with carbinoxamine. In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention.[1]

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[2] Whether lower oral doses of carbinoxamine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Carbinoxamine Identification

Substance Name

Carbinoxamine

CAS Registry Number

486-16-8

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

40

Last Revision Date

20150310

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