Why can't you drink grapefruit juice with a lot of medications?
Question posted by Tgood36 on 20 hours ago
Last updated on 6 May 2025 (11 hours ago) by masso
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Answers
masso
11 hours ago
Hello,
Many drugs are broken down (metabolized) with the help of a vital enzyme called CYP3A4 in the small intestine. Grapefruit juice can block the action of intestinal CYP3A4, so instead of being metabolized, more of the drug enters the blood and stays in the body longer. The result: too much drug in your body.
Source: U.S. FDA
Regards, masso
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grapefruit, medication, grapefruit juice
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