You asked what substances, medications and/or intakes can skew PSA test results? The answer is a number of things that I will mention later. But the place to start is with the PSA test itself. You should discuss the pros and cons of having this test undertaken in the first place with your doctor. PSA tests are not totally reliable and often suggest the presence of prostate cancer when no cancer exists (a false-positive result). This means a number of men often have invasive and sometimes painful biopsies for no reason. That said prostate cancer in the early stages often show no signs or symptoms. Prostate cancer can grow slowly or very quickly. Most prostate cancer are slow-growing to start with and may never cause any symptoms or problems in a man's lifetime. A raised PSA level can be a sign of prostate cancer or a prostate problem. But some men with a normal PSA level can also have prostate cancer. This is why one must discuss having a PSA test with their doctor first.
What can skew a PSA result?
The PSA test itself
Urine infection – The doctor should treat this before PSA test is undertaken
An enlarged prostate
Prostatitis – Inflammation of the prostate gland
Vigorous exercise – You may need to avoid for 48 hours before test. Vigorous exercise can raise PSA level.
Ejaculation - You may be asked to avoid sexual activity for 48 hours before the PSA test.
Biopsy - Prostate biopsy six weeks before a PSA test could affect the result.
A urine catheter, investigations or operations on your bladder or prostate -You may need to wait up six weeks before having a PSA test.
Medications – You must tell your doctor if you are taking any prescription or over-the-counter medicines.
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