Prednisolone - how long does it take to clear your body?

The literature states that prednisolone as well as other corticosteroids has a life as follows:

"Other corticoids, including methylprednisolone, hydrocortisone, Prednisone, and prednisolone, are considered to be short acting (producing adrenocortical suppression for 1 1/4 to 1 1/2 days following a single dose) and thus are recommended for alternate day therapy."

I believe my friend meant to say day rather than hour. :-)

All of these are to be taken in the morning and with food. High doses are split evenly through the day, generally over 25 or 30mg and higher, the doc will let you know. Morning is needed because of how our body works during the night. Taking in the morning provides the most effective course of action and smallest dose to control the condition.

Be sure to take your meds as described and stay well. Do more reading on prednisone. The long term higher doses cause the side effects. Short term dose packs have not the side effect. For the next year, be sure to tell every doctor you see when you were on prednisone. If long term, be sure they know your current dose. And never, ever just stop. Taper as you are told by the doctor. Very serious not to do so. Hope you improve soon, Karen

Prednisone has a short half life of 1 hour, and most of it is cleared by the body in about 5-6 half lives or 5-6 hours. Almost all of it is gone in about 10 hours after the last dose.