I need to know the Route, Onset, and Peak of this drug?
I think the following answers your questions:
Well absorbed following oral administration, with peak plasma concentration attained within 10–60 minutes (immediate-release preparations) or 60–120 minutes (extended-release preparations).a
Poor or variable absorption following rectal administration; considerable variation in peak plasma concentrations attained; time to reach peak plasma concentration is substantially longer than after oral administration.
Food may delay absorption following administration as extended-release tablets.148
Rapidly distributed to most body tissues.a Crosses placenta and is distributed into breast milk.198
Plasma Protein Binding
Metabolized principally by sulfate and glucuronide conjugation; 226 small amounts (5–10%) oxidized by CYP-dependent pathways (mainly CYP2E1 and CYP3A4) to a toxic metabolite, N-acetyl-p-benzoquinoneimine (NAPQI).226 NAPQI is detoxified by glutathione and eliminated; any remaining toxic metabolite may bind to hepatocytes and cause cellular necrosis.121 226
Mainly excreted in urine as conjugates.
- Acetaminophen Information for Consumers
- Acetaminophen Information for Healthcare Professionals (includes dosage details)
- Side Effects of Acetaminophen (detailed)
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