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Does oxycodone cause side effect in liver?

Responses (2)

Oxycodone is not good for your liver. Oxycodone can cause liver enzyme elevations. It's even worse when oxycodone is used heavily or in junction with acetaminophen.

Anonymous 6 Jan 2013

Hello kit843 & welcome to the site. If you are having liver problems oxycodone is not the best med to be taken. I am copying part of whta the FDA monograph has to say bout it to get it right:

Metabolism

Extensively metabolized in the liver to noroxycodone and oxymorphone and their glucuronide conjugates.

Oxymorphone formation mediated by CYP2D6;g approximately 10 times as potent as morphine parenterally and likely contributes to oxycodone’s effects.g

Elimination Route

Oxycodone and its metabolites excreted principally in urine.

Half-life

Conventional preparations: 3.2–5 hours.b g

Extended-release tablets (e.g., OxyContin): apparent half-life 4.5–8 hours.g

Special Populations

Renal impairment: elimination half-life increased by 1 hour compared with normal renal function.g Peak plasma concentrations and AUCs for oxycodone and noroxycodone increased substantially.g

Mild to moderate hepatic impairment: the elimination half-life was increased by 2.3 hours compared with normal hepatic function.g Peak plasma concentrations and AUCs for oxycodone and noroxycodone increased but less substantially than with hepatic impairment.g
Wishing you the best...

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