What is the onset and duration of Carvedilol ?
- 15 Jul 2013 by bikermedic61
- 16 July 2013
Carvedilol is rapidly and extensively absorbed following oral administration, with absolute bioavailability of approximately 25% to 35% due to a significant degree of first-pass metabolism. Following oral administration, the apparent mean terminal elimination half-life of Carvedilol generally ranges from 7 to 10 hours. Plasma concentrations achieved are proportional to the oral dose administered. When administered with food, the rate of absorption is slowed, as evidenced by a delay in the time to reach peak plasma levels, with no significant difference in extent of bioavailability. Taking Carvedilol tablets with food should minimize the risk of orthostatic hypotension.
Full information is given under pharmacokinetics in the link below.
- Carvedilol Information for Consumers
- Carvedilol Information for Healthcare Professionals (includes dosage details)
- Side Effects of Carvedilol (detailed)
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