Monistat-1 - How long do you have to lay in bed after using monistat 3 also why does it burn so bad?

The answer is all night or when you normally go to sleep. It would be a good idea not to drink anything beforehand so that you will not have to get up and pee You will lose some medicine if you do.

You're supposed to put in at bedtime, so you aren't getting up again. It burns because the infection has made you irritated.