I take 2 in the morning and 2 in the evening just wondering what I am doing wrong to make them not dissolve and therefore not do there job.
This is the most common question about Metformin I myself have noticed. I have seen this question on this forum so many times. I think it would be a great idea if this side effect would be printed on the information pamphlet when you pick up this medication. Or even a label on the prescription bottle itself. If I was a Pharmacist, I would mention to my customers to not be alarmed and explain this side effect is common.
Are you on Metformin Extended Release? Then it is just the polymer matrix you see in your stool. All of the drug has been absorbed. This is a common release mechanism for certain drugs to make them extended release. If they were not working, your blood sugar results would be sky high. Here it is in the literature:
System Components and Performance - Metformin HCl extended release tablets, USP comprises a dual hydrophilic polymer matrix system. Metformin HCl is combined with a drug release controlling polymer to form an "inner" phase, which is then incorporated as discrete particles into an "external" phase of a second polymer. After administration, fluid from the gastrointestinal (GI) tract enters the tablet, causing the polymers to hydrate and swell. Drug is released slowly from the dosage form by a process of diffusion through the gel matrix that is essentially independent of pH. The hydrated polymer system is not rigid and is expected to be broken up by normal peristalsis in the GI tract. The biologically inert components of the tablet may occasionally remain intact during GI transit and will be eliminated in the feces as a soft, hydrated mass.
Are your pills round and if you look, in the center, is there a tiny dot? If so, you have an "osmotic" tablet. As the pill moves through your system, the medication comes out of the tiny hole(s) and enters your bloodstream. What's left is additional medication and the shell, which (I remember the instructions saying) you should expect to see eliminated in fecal material.
- Metformin Information for Consumers
- Metformin Information for Healthcare Professionals (includes dosage details)
- Side Effects of Metformin (detailed)
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