I take 2 in the morning and 2 in the evening just wondering what I am doing wrong to make them not dissolve and therefore not do there job.
This is the most common question about Metformin I myself have noticed. I have seen this question on this forum so many times. I think it would be a great idea if this side effect would be printed on the information pamphlet when you pick up this medication. Or even a label on the prescription bottle itself. If I was a Pharmacist, I would mention to my customers to not be alarmed and explain this side effect is common.
Are you on Metformin Extended Release? Then it is just the polymer matrix you see in your stool. All of the drug has been absorbed. This is a common release mechanism for certain drugs to make them extended release. If they were not working, your blood sugar results would be sky high. Here it is in the literature:
System Components and Performance - Metformin HCl extended release tablets, USP comprises a dual hydrophilic polymer matrix system. Metformin HCl is combined with a drug release controlling polymer to form an "inner" phase, which is then incorporated as discrete particles into an "external" phase of a second polymer. After administration, fluid from the gastrointestinal (GI) tract enters the tablet, causing the polymers to hydrate and swell. Drug is released slowly from the dosage form by a process of diffusion through the gel matrix that is essentially independent of pH. The hydrated polymer system is not rigid and is expected to be broken up by normal peristalsis in the GI tract. The biologically inert components of the tablet may occasionally remain intact during GI transit and will be eliminated in the feces as a soft, hydrated mass.
Are your pills round and if you look, in the center, is there a tiny dot? If so, you have an "osmotic" tablet. As the pill moves through your system, the medication comes out of the tiny hole(s) and enters your bloodstream. What's left is additional medication and the shell, which (I remember the instructions saying) you should expect to see eliminated in fecal material.
Whoever is answering this is not understanding AT ALL!!! These are the Metformin tablets:
In case the pic doesn't show up or the link won't work, they are "horse pills", not the small tabs or caps you're thinking of.
There are NO HOLES!
They DO NOT break down or otherwise release any medication!
They have a THICK COATING! Not some thin outer shell that comes off and allows for absorbtion!
They are FULLY INTACT when found in our stool!
They are more plump from absorbing water, but not broken down at all. The powder/medication is still FULLY INTACT upon breaking open the tablet!
I'm going to research this somewhere else on the web and then call my pharmacist or DR.
I hope this cleared some things up for those of you who weren't understanding what was being described. Not trying to be rude. I just know how frustrating it can be when you're explaining a problem and people aren't grasping what you're saying. As I'm having the same issue, it was twice as frustrating.
My mother also takes the horse pill of metformin, and has the same complaint of finding it in her stool. So I took one of them and put it in a cup of water. 3 days later it was still in tact and solid. I took a knife to it and it was still hard to cut. I personally don't believe this stuff works if it won't dissolve.
I think there is just a slight communication problem here. As I understand it from the explanations above, the actual medicine is mixed into this 'vesel' which looks like a pill. The material that the pill is made of is non-dissolvable, because this is the method they use to ensure that only a little bit of the medicine is released at a time - hence extended release.
So as your digestive juices start working on this pill, it softens little by little, releasing the medicine as it does. Once it reachesthe end of your digestive tract, the medicine has all been released, but this non-dissolvable 'pill' gets excreted. In normal digestive functions, once it reaches the end of your tract, it would have become so soft, that it is broken down into smaller bits by the contraction of your bowels moving the matter down.
But, when you have diarrea, the pill moves through your system faster, so it's not yet as soft and broken down when it reaches the end, and this is when it comes out "whole". So basically, it's normal. That's how it's supposed to be. We just don't always see it. :)
- Metformin Information for Consumers
- Metformin Information for Healthcare Professionals (includes dosage details)
- Side Effects of Metformin (detailed)
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