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Is keflex in the same family as cipro?

Responses (2)

DzooBaby 17 Apr 2014

No. Keflex is a cephalosporin and Cipro is a fluoroquinalone

Malindalang 17 Apr 2014

Found this for you... I was told by Dr. that they are in the same class and to not take them... yes--it is a Cet. but they have similar actions ect.
Abstract

Cephalosporin 3'-quinolone esters, carbamates, and tertiary amines are potent antibiotics whose antibacterial activities reflect the action of both the beta-lactam and the quinolone components. The biological properties of representative compounds from each class were compared in Escherichia coli. All compounds bound to the essential PBP 3, inhibited DNA gyrase, and caused filamentation in growing cells. To distinguish between cephalosporin- and quinolone-induced filaments, nucleoid segregation was also examined, as quinolones disrupt nucleoid segregation while the beta-lactams do not (N. H. Georgopapadakou and A. Bertasso, Antimicrob. Agents Chemother. 35:2645-2648, 1991). The cephalosporin quinolone esters Ro 23-9424 and Ro 24-6392, at concentrations causing filamentation in E. coli ATCC 25922, did not affect nucleoid segregation after 1 h of incubation (cephalosporin response) but did not affect it after 2 h (quinolone response), indicating the release of free quinolone. Accordingly, only the quinolone response was produced in a strain possessing TEM-3, an expanded-spectrum beta-lactamase. The cephalosporin carbamate Ro 24-4383 and the tertiary amine Ro 24-8138 produced a quinolone response in E. coli ATCC 25922, though they produced a cephalosporin response in a quinolone-resistant strain. Carbamate and tertiary amine linkages are chemically more stable than the ester linkage, and both cephalosporin 3'-quinolone carbamates and tertiary amines are more potent inhibitors of DNA gyrase than are the corresponding esters. The results suggest that, while intact cephalosporin 3'-quinolone esters act as cephalosporins, carbamates and amines may possess both cephalosporin and quinolone activity in the intact molecule.

DzooBaby 18 Apr 2014

Cephalosporins and fluoroquinalones are different classes. Here is an answer from a Dr to a person asking about other antibiotics when sensitive to keflex:

Antibiotics are in a number of chemical classes. With a severe reaction to keflex (also called cefazolin), you should avoid antibiotics in the cephalosporin and probably the penicillin class, as there is a higher chance of cross reactivity. Typically, we will give antibiotics in a different chemical class rather than testing. For you, examples may be clindamycin, ciprofloxacin or vancomycin.

So he is saying he would give cipro!

DzooBaby 18 Apr 2014

Here is another answer from a different Dr about cross allergies:
Keflex (cephalexin) is a member of cephalosporin family of antibiotics which are cousins to penicillins. Be sure to tell your doctors about your all your (drug) allergies, especially types of reactions. We're most concerned about anaphylaxis. In the future, if necessary & appropriate, you can take unrelated sulfa, mycins & quinolone type antibiotics. (cipro is a quinalone)

DzooBaby 18 Apr 2014

Another example:
Options for True Penicillin
Allergy Patients
• 2nd or 3rd generation cephalosporin
• Sulfamethoxazole/trimethoprim (Bactrim or
Septra)
• A fluoroquinolone (Levofloxacin)
• Doxycycline
• Erythromycin

Besides the poster asked nothing about allergies, she asked about classes and these medications are CLASSED differently! Keflex is a cephalosporin and Cipro is a fluoroquinolone-two different classes!

kaismama 18 Apr 2014

This isn't even allergies, this is how it acts against bacteria. We aren't bacteria and fluoroquinolones and cephalosporins aren't even cousins when it comes to their class.

DzooBaby 18 Apr 2014

I read this whole article you are posting a piece of here, Malindalang, and it is not talking about the drugs already on the market. It is talking about developing new drugs by combining types of drugs already on the market to use against organisms resistant to cephalosporins and quinalones NOT that cephalosporins and quinalones are the same thing!

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