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IS it safe to take cialis if taking Lisinopril 5 MG for high blood pressure?

Responses (2)

Anonymous 3 Sep 2010

Hello,

Monitor minor between selected drugs.-
monitor moderate with food.-

Interactions between your selected drugs

lisinopril ↔ tadalafil
Applies to: lisinopril, Cialis (tadalafil)
Based on their pharmacology, phosphodiesterase-5 (PDE5) inhibitors may conceivably potentiate the hypotensive effect of antihypertensive medications. These agents inhibit PDE5-mediated degradation of cyclic guanosine monophosphate (cGMP), which in vascular smooth muscles can cause peripheral vasodilation. However, clinical pharmacology studies of tadalafil (administered as a 10 mg dose except in studies with angiotensin II receptor (AR) blockers and amlodipine, which used a dose of 20 mg) have demonstrated no clinically significant interaction with various antihypertensive drugs from major classes including calcium channel blockers, ACE inhibitors, beta blockers, thiazide diuretics, and AR blockers. Tadalafil 10 mg and 20 mg also had no clinically significant effect on blood pressure changes due to tamsulosin, an alpha-1a blocker. In addition, analysis of data from Phase 3 clinical trials showed no difference in adverse events in patients taking tadalafil with or without antihypertensive medications. In patients receiving concomitant antihypertensive medications, tadalafil 20 mg may induce a blood pressure decrease that is, in general, minor and not likely to be clinically relevant. In a clinical study of healthy male subjects 45 to 78 years of age, administration of silodosin with a single 20 mg dose of tadalafil resulted in increased frequency of positive orthostatic test results during a 12-hour period following concomitant dosing compared to administration with placebo. No events of symptomatic orthostasis or dizziness were reported in subjects receiving silodosin with tadalafil. Nevertheless, patients should be advised of the potential for interaction and to contact their doctor if they experience symptoms of hypotension such as dizziness, lightheadedness, or fainting.

Other drugs that your selected drugs interact with

lisinopril interacts with more than 200 other drugs.
Cialis (tadalafil) interacts with more than 100 other drugs.
Interactions between your selected drugs and food

lisinopril ↔ food
Applies to: lisinopril
GENERALLY AVOID: Moderate-to-high dietary intake of potassium can cause hyperkalemia in some patients who are using angiotensin converting enzyme (ACE) inhibitors. In some cases, affected patients were using a potassium-rich salt substitute. ACE inhibitors can promote hyperkalemia through inhibition of the renin-aldosterone-angiotensin (RAA) system.

MANAGEMENT: It is recommended that patients who are taking ACE inhibitors be advised to avoid moderately high or high potassium dietary intake. Particular attention should be paid to the potassium content of salt substitutes.

tadalafil ↔ food
Applies to: Cialis (tadalafil)
MONITOR: Grapefruit juice may increase the plasma concentrations of some orally administered drugs that are primarily metabolized by the CYP450 3A4 isoenzyme. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. The extent and clinical significance of many of these interactions are unknown. Moreover, pharmacokinetic alterations associated with interactions involving grapefruit juice are often subject to a high degree of interpatient variability.

Take care

Read more: https://www.drugs.com/interactions-check.php?drug_list=1476-0,2144-1395#ixzz0yQYA8ajo

bollard 5 Sep 2010

I have been taking viagra, once a week or so at 50 mg, along with lisinopril 5 mg.every day for several years now and have had no side effects. Hope this helps.

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