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Ipratropium - Mechanism of action?


Marvell 22 Sep 2009

Ipratropium bromide monohydrate. It is an anticholinergic bronchodilator, chemically related to atropine.

Ipratropium bromide is an anticholinergic (parasympatholytic) agent that, based on animal studies, appears to inhibit vagally mediated reflexes by antagonizing the action of acetylcholine, the transmitter agent released from the vagus nerve.

Anticholinergics prevent the increases in intracellular concentration of cyclic guanosine monophosphate (cyclic GMP) that are caused by interaction of acetylcholine with the muscarinic receptor on bronchial smooth muscle.

The bronchodilation following inhalation of Ipratropium bromide is primarily a local, site-specific effect, not a systemic one. Much of an administered dose is swallowed but not absorbed, as shown by fecal excretion studies.

Votes: +1
Marvell 22 Sep 2009

I hope the above answers your question.

Kerrydolly 23 Sep 2009

Thanks a lot. U have helped a lot. Pls keep in touch!

jaliceII 17 May 2012

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Related topics

chronic obstructive pulmonary disease, ipratropium

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