Ipratropium - Mechanism of action?
- 22 Sep 2009 by Kerrydolly
- 17 May 2012
- ipratropium, chronic obstructive pulmonary disease, maintenance
Ipratropium bromide monohydrate. It is an anticholinergic bronchodilator, chemically related to atropine.
Ipratropium bromide is an anticholinergic (parasympatholytic) agent that, based on animal studies, appears to inhibit vagally mediated reflexes by antagonizing the action of acetylcholine, the transmitter agent released from the vagus nerve.
Anticholinergics prevent the increases in intracellular concentration of cyclic guanosine monophosphate (cyclic GMP) that are caused by interaction of acetylcholine with the muscarinic receptor on bronchial smooth muscle.
The bronchodilation following inhalation of Ipratropium bromide is primarily a local, site-specific effect, not a systemic one. Much of an administered dose is swallowed but not absorbed, as shown by fecal excretion studies.
- Ipratropium Information for Consumers
- Ipratropium Information for Healthcare Professionals (includes dosage details)
- Side Effects of Ipratropium (detailed)
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