How long before the side effects wear off with using nitrofurantoin?
Question posted by tarrantella on 6 Feb 2012
Last updated on 27 July 2022 by Sassyblonde
Just was told to stop this drug immediately Monday evening after being on it 4 days. It was prescribed for a mild uti with no fever, just some discomfort. 24 hours later I was nauseated, very weak, a rash developed, with a 101.4 fever…by the next day, I thought about going into ER. Never associated the symptoms with the drug, kept thinking I would get better. Nothing improved so I contacted the doctor and we realized it was nitrofurantoin causing my issues. I would say….user beware. I have never had an issue with any drug, until this one. Now 48 hours after my last dose, I am still weak, somewhat nauseated, the rash still persists, but at least my fever has been normal now for 24 hours.
The illness I have felt from this drug the past few days has been debilitating.
The drug can stay in your system for 24 hours they say.
I took this med two doses and was puking my brains out. So I called the doctor they said try a probiotic and yogurt so I did and the next day same thing but I was also having chest pain/tightness and short of breath. So I called the doctor again. And demanded I be switched to something else and this drug be added to my adverse reaction list.
I hear it’s very common for this drug to cause some very disturbing side effects. I don’t know why it’s not black box yet by the FDA cause so many people have issues with this medication. If you are a person with any sort of stomach issues I highly recommend to say no to taking this drug before taking it cause I don’t want anyone to feel how I feel right now.
I was prescribed nitrofurantoin for a uti and took the first dose in the morning and went about my day. It was mid morning when I felt nauseated. I didn't attribute it to the medication so continued taking the prescribed dosage. That evening I went to bed early with a pounding headache and nausea. The next morning I felt a little better and took the morning dosage and within the hour the nausea and headache returned in addition to diarrhea, abdominal pain, no appetite I lost 5lbs in four days, bad breath, fatigue, and facial itching. I stopped taking the medication and called my pcp for another medication. I stopped taking the meds two days ago and still feel lingering side effects. I wish I would feel better soon.
I too took this medication prescribed two a Day first took two noticed nausea but went ahead and took another dose next day oh my I got nausea dizziness and sweaty it’s been 2 days now still notice nausea usually in the morning be so glad when this medication is out of my system so glad I stopped taking it oh by the way I did have food in my stomach
I’m hoping to find out how long it will take Macrobid side effects to wear off as well. I also want to share my experiences so it will help others. In April 2017 I ended up in the hospital w/ Urosepsis. Some of the same symptoms I’ve had recently with this UTI and past are similar to my symptoms when I had Urosepsis. Because I almost died I don’t mess around a UTI! This current UTI started in mid November 2018. The first culture came back multi-antibiotic resistant. Besides Macrobid there were few options, mainly just IV antibiotics. I was prescribed a 5 day course 100mg two times a day. I finished the course and felt worse while on it and it didn’t resolve the UTI and I got very sick the following day & ended up back at ER. Where they told me that my urine showed no infection but went ahead and prescribed me a antibiotic Cefdnir. That worked for the 5 days, but again the next day the UTI was back.
In the middle of the night I was sick w/ shakes, fever, chills & rapid heart rate, back to ER again being told my urine was clean. All labs and CAT scan were clear. They prescribed me a new antibiotic Cefpodoximine. 3 days on this I felt worse & did not sleep w/ racing heart & chest pain. Back to ER again where they said my urine was clean, but diagnosed me w/Trycardia
& all labs clean. They could not explain the Trycardia. Dr. Said stay on antibiotic & also added 100 mg of Macrobid & said to take both & when the Cefpodoximine was done continue Macrodid for a month. Meanwhile I was trying to hang on with my life to get into my infectious disease dr. I couldn’t get in till 12/18/18. I ended up in ER 3 times after the first course of Macrobid always assuming the shakes, chills, heart palpitations, chest pain, dizziness, muscle weakness and cold feet and sometimes hot and flushed all over were symptoms of the UTI not being resolved. I finally got in to my infectious disease DR. last Tuesday, who told me to get off the Macrobid because he wanted a clean urine sample & because I was leaving town for the holidays that I could go back on it after the urine sample was done. I would see him after the New Year. I stopped the Macrobid for 2 days & was so sick again assuming it was the unresolved UTI. I did my urine sample & immediately went back on it. Yesterday, I felt well all day except lower back pain & some random pain along my spine.
Before bed I went to the bathroom, my pee burned and I all of the sudden felt sick, my temp jumped to 99.9 and started w/ the shakes. Bad chest pain and tightness. My blood pressure jumped. I assumed it’s now a Kidney infection because of the back pain earlier in the day & I’ve been dealing w/ this for a month & again out of desperation went to ER. Where all labs, culture & Cat scan were clear. I knew chest pain was a side effect of Macrobid & was willing to deal w/ it to kill off the UTI. But after researching that the chest pain is actually a symptom of Pulmonary Toxcity and seeing some other people report similar symptoms w/ Macrobid I’m certain it’s been the Macrobid that has caused all the horrible symptoms I’ve dealt with. It seems the longer your on it the worse the side effects are and they linger even when your off it. I’ve delayed my Xmas vacation by a week hoping the side effects will be resolved.
I took this medication in March 2018 and still have horrible hand pain in both hands.
I have issues with opening things that need to be twisted with some force, turning a door knob, putting on sheets on the bed, taking things out of the washer and putting into the dryer, etc. They feel as if they are badly sprained. I thought by now this would go away but it has not.
Does anyone else have painful hands after being off of this medication for multiple months?
My next step is to try acupuncture to see if that will help.
I took Macrobid and wound up in the hospital for severe nausea and vomiting. Doctor didn’t think it was the drug, so he told me to keep taking it. I had severe body aches, high fevers, chills, nausea, and shortness of breath. I am 36 hours out from the last dose and finally seem to be improving a bit.
Does this medication breakup red blood cells?
What kind of side effects are you having? Were you using this to treat a UTI?
Here is what the literature says about side effects:
In clinical trials of Macrobid (nitrofurantoin) , the most frequent clinical adverse events that were reported as possibly or probably drug-related were nausea (8%), headache (6%), and flatulence (1.5%). Additional clinical adverse events reported as possibly or probably drug-related occurred in less than 1% of patients studied and are listed below within each body system in order of decreasing frequency:
Gastrointestinal: Diarrhea, dyspepsia, abdominal pain, constipation, emesis
Neurologic: Dizziness, drowsiness, amblyopia
Respiratory:Acute pulmonary hypersensitivity reaction (see WARNINGS)
Allergic: Pruritus, urticaria
Miscellaneous: Fever, chills, malaise
The following additional clinical adverse events have been reported with the use of nitrofurantoin:
Gastrointestinal: Sialadenitis, pancreatitis. There have been sporadic reports of pseudomembranous colitis with the use of nitrofurantoin. The onset of pseudomembranous colitis symptoms may occur during or after antimicrobial treatment. (See WARNINGS.)
Neurologic: Peripheral neuropathy, which may become severe or irreversible, has occurred. Fatalities have been reported. Conditions such as renal impairment (creatinine clearance under 60 mL per minute or clinically significant elevated serum creatinine), anemia, diabetes mellitus, electrolyte imbalance, vitamin B deficiency, and debilitating diseases may increase the possibility of peripheral neuropathy. (See WARNINGS.)
Asthenia, vertigo, and nystagmus also have been reported with the use of nitrofurantoin.
Benign intracranial hypertension (pseudotumor cerebri), confusion, depression, optic neuritis, and psychotic reactions have been reported rarely. Bulging fontanels, as a sign of benign intracranial hypertension in infants, have been reported rarely.
CHRONIC, SUBACUTE, OR ACUTE PULMONARY HYPERSENSITIVITY REACTIONS MAY OCCUR WITH THE USE OF NITROFURANTOIN.
CHRONIC PULMONARY REACTIONS GENERALLY OCCUR IN PATIENTS WHO HAVE RECEIVED CONTINUOUS TREATMENT FOR SIX MONTHS OR LONGER. MALAISE, DYSPNEA ON EXERTION, COUGH, AND ALTERED PULMONARY FUNCTION ARE COMMON MANIFESTATIONS WHICH CAN OCCUR INSIDIOUSLY. RADIOLOGIC AND HISTOLOGIC FINDINGS OF DIFFUSE INTERSTITIAL PNEUMONITIS OR FIBROSIS, OR BOTH, ARE ALSO COMMON MANIFESTATIONS OF THE CHRONIC PULMONARY REACTION. FEVER IS RARELY PROMINENT.
THE SEVERITY OF CHRONIC PULMONARY REACTIONS AND THEIR DEGREE OF RESOLUTION APPEAR TO BE RELATED TO THE DURATION OF THERAPY AFTER THE FIRST CLINICAL SIGNS APPEAR. PULMONARY FUNCTION MAY BE IMPAIRED PERMANENTLY, EVEN AFTER CESSATION OF THERAPY. THE RISK IS GREATER WHEN CHRONIC PULMONARY REACTIONS ARE NOT RECOGNIZED EARLY.
In subacute pulmonary reactions, fever and eosinophilia occur less often than in the acute form. Upon cessation of therapy, recovery may require several months. If the symptoms are not recognized as being drug-related and nitrofurantoin therapy is not stopped, the symptoms may become more severe.
Acute pulmonary reactions are commonly manifested by fever, chills, cough, chest pain, dyspnea, pulmonary infiltration with consolidation or pleural effusion on x-ray, and eosinophilia. Acute reactions usually occur within the first week of treatment and are reversible with cessation of therapy. Resolution often is dramatic. (See WARNINGS.)
Changes in EKG (e.g., non-specific ST/T wave changes, bundle branch block) have been reported in association with pulmonary reactions.
Cyanosis has been reported rarely.
Hepatic: Hepatic reactions, including hepatitis, cholestatic jaundice, chronic active hepatitis, and hepatic necrosis, occur rarely. (See WARNINGS.)
Allergic: Lupus-like syndrome associated with pulmonary reaction to nitrofurantoin has been reported. Also, angioedema; maculopapular, erythematous, or eczematous eruptions; anaphylaxis; arthralgia; myalgia; drug fever; and chills have been reported. Hypersensitivity reactions represent the most frequent spontaneously-reported adverse events in worldwide postmarketing experience with nitrofurantoin formulations.
Dermatologic: Exfoliative dermatitis and erythema multiforme (including Stevens-Johnson syndrome) have been reported rarely.
Hematologic: Cyanosis secondary to methemoglobinemia has been reported rarely.
Miscellaneous: As with other antimicrobial agents, superinfections caused by resistant organisms, e.g., Pseudomonas species or Candida species, can occur.
In clinical trials of Macrobid (nitrofurantoin) , the most frequent laboratory adverse events (1-5%), without regard to drug relationship, were as follows: eosinophilia, increased AST (SGOT), increased ALT (SGPT), decreased hemoglobin, increased serum phosphorus. The following laboratory adverse events also have been reported with the use of nitrofurantoin: glucose-6-phosphate dehydrogenase deficiency anemia (see WARNINGS), agranulocytosis, leukopenia, granulocytopenia, hemolytic anemia, thrombocytopenia, megaloblastic anemia. In most cases, these hematologic abnormalities resolved following cessation of therapy. Aplastic anemia has been reported rarely.
As far as how fast the side effects clear would depend on which ones you have. Most mild side effects should clear fairly quickly.
- Nitrofurantoin uses and safety info
- Nitrofurantoin information for Healthcare Professionals (includes dosage details)
- Side effects of Nitrofurantoin (detailed)
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