Tramadol is extensively metabolized after oral administration. The major metabolic pathways appear to be N – (mediated by CYP3A4 and CYP2B6) and O – (mediated by CYP2D6) demethylation and glucuronidation or sulfation in the liver.
Tramadol is eliminated primarily through metabolism by the liver and the metabolites are eliminated primarily by the kidneys. Approximately 30% of the dose is excreted in the urine as unchanged drug, whereas 60% of the dose is excreted as metabolites. The remainder is excreted either as unidentified or as unextractable metabolites.
- Tramadol Information for Consumers
- Tramadol Information for Healthcare Professionals (includes dosage details)
- Side Effects of Tramadol (detailed)
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
Posted 13 Nov 2013 • 1 answer
Why is Advil bad for your kidneys if it is processed by the liver and Tylenol not so harmful when i?
Posted 10 Jan 2014 • 1 answer
Posted 27 Apr 2014 • 1 answer
Posted 19 Aug 2014 • 3 answers
Posted 30 Jan 2015 • 5 answers