I have heard that grapefruit juice can enhance the effect of tramadol. And on the other side I’ve heard it can decrease the effects of it. Which is true?
How grapefruit juice effects tramadol?
Question posted by Sean1122 on 10 Oct 2018
Last updated on 10 October 2018 by Stephen Treloar
Answers
It can potentially increase blood plasma levels of Tramadol if you take more after ingesting grapefruit as it affects/interferes with the metabolism of the drug . So it will not increase the effects of Tramadol that you have already taken but will slow down your liver's ability to break it down leading to higher than normal sustained blood plasma levels. This is not a good thing as drug guidance and dosing information is based on normal metabolism.
You can read about the specific action of grapefruit here: https://www.drugs.com/article/grapefruit-drug-interactions.html
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grapefruit, tramadol, grapefruit juice
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