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You can take Tylenol and Advil together. They even work better in combination than separately. Several large studies have shown that ibuprofen (Advil, Motrin) and acetaminophen (Tylenol) together work well to relieve pain, with few side effects. The combination is safe because, acetaminophen is cleared by the liver, while ibuprofen is cleared by the kidneys. Each medication works differently and they are broken down differently so there is minimal concern here.
There are no significant interactions between these two drugs, and because they have different mechanisms of action, it is safe to take Flexeril and Tylenol together if doctor prescribed them.
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