I have been taking Topamax (topiromate) for about 3 months now for migraines and I have gradually increased from 25 to 50 to 100 and am now on 200 mg per day. It is directed that I take 100mg in the morning and 100mg at night, but as long as I have been on the medication I have always taken it at night as it makes me tired and dizzy and I would find it hard to complete my daily routine while on the drug. So I have been taking 2x 100mg tablets at night and I was wondering if this will affect me in anyway or perhaps make the medication less effective? I have also lost about 17lb while on the medication but would like to lose more, does taking the medication at night make it more or less likely that I will lose weight on this drug or does it make no difference?