I take 10 mg of Amlodipine once daily in the morning, I understand grapefruit and beta blockers do not "get along". But Amlodipine is a calcium channel blocker, so am I okay to eat grapefruit or should I avoid it?
There is a minor interaction,meaning:
The consumption of grapefruit juice may slightly increase plasma concentrations of amlodipine. The mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. Data have been conflicting and the clinical significance is unknown. Monitoring for calcium channel blocker adverse effects (e.g., headache, hypotension, syncope, tachycardia, edema) is recommended.
Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Always consult with your DR. or Pharmacist/Chemist.
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
Posted 13 Dec 2010 • 2 answers
Posted 8 Jan 2013 • 5 answers
Posted 5 May 2013 • 1 answer
Posted 7 Jul 2014 • 1 answer
Posted 3 Jun 2016 • 1 answer