I take 10 mg of Amlodipine once daily in the morning, I understand grapefruit and beta blockers do not "get along". But Amlodipine is a calcium channel blocker, so am I okay to eat grapefruit or should I avoid it?
Can I eat grapefruit while taking Amlodipine daily?
Question posted by grandmaof10 on 23 May 2013
Last updated on 2 September 2017 by Siggsy
When I pick up my meds from the chemist, my box of Amlodipine specifically states "avoid eating grapefruit and/or drinking grapefruit juice, so if I were you, I would totally avoid grapefruit containing products.
There is a minor interaction,meaning:
The consumption of grapefruit juice may slightly increase plasma concentrations of amlodipine. The mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. Data have been conflicting and the clinical significance is unknown. Monitoring for calcium channel blocker adverse effects (e.g., headache, hypotension, syncope, tachycardia, edema) is recommended.
Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your health care provider can determine if adjustments to your medications are needed.
Always consult with your DR. or Pharmacist/Chemist.
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