Glutathione is a naturally occuring tripeptide produced in the liver. Its main role is to neutralise toxins in the body. It achieves this through its anti-oxidant and free-radical scavenging properties.
Glutathione can be obtained through diet (fresh fuit & veges, cooked fish & meat) and through synthesis.
It is unclear whether glutathione supplements are well absorbed or beneficial in healthy individuals.
Supplementation may be useful to patients where anti-oxidants are beneficial eg AIDS, chemotherapy, drug overdose.
Supplements have to been given where there is liver damage but results non-conclusive.
Milk thistle is used as a liver protectant and as an anti-oxidant.
Glutathione is a protein in each of your cells, and it is made from the three amino acids cysteine, glutamine, and glycine. Of these three, cysteine is the hardest to get in a form that your cells can use to make glutathione.
In order to raise your glutathione in your cells, you must give yourself the building blocks or precursors for intracellular glutathione synthesis. The most thoroughly studied forms of cysteine to raise glutathione are N Acetyl-Cysteine, or NAC, which is a drug that you can get at the health food store, and bonded cysteine, which is a medicinal food or nutraceutical called Immunocal.
Taking oral glutathione is destroyed in the gut and will not raise your glutathione. Glutathione is highest in your liver and kidneys, your main organs of detoxification, and by binding to the toxins in your body with an enzyme called conjugase, glutathione does help the liver to do its job of detoxification.
Milk thistle is a precursor or building block for glutathione, so if you take milk thistle, it can have an impact, but not as great of an impact as if you used one of the two forms of cysteine above.
I am going to share everything what I know about this, but I notify you Gluthation has different functions and it has two different type one:
You can find Gluthation many food sach as veges and meat in,
and your body makes it in the body cells from 3 different Amino acid for your immune system, read more here or visit my site to learn about it, ask me :) whatisgluthation.com
Actualy it is made in side your body cell which one type Gluthation has detoxifaciton skill :) we use to say Gluthation is a humand AID
I : Immune booster
however Gluthation is the Mother Of every antioxidant
Your life depends on glutathione.Without it,your cells would disintegrate from unrestrained oxidation,
Glutathione is a tripeptide made intracellularly from its constituent amino acids Lglutamate,
L-cysteine and glycine. The sulfhydryl (thiol) group (SH) of cysteine is
responsible for the biological activity of glutathione. Provision of this amino acid is the
rate-limiting factor in glutathione synthesis by the cells since bioavailable cysteine is relatively rare in foodstuffs.
Immunocal® is a bovine whey protein isolate specially prepared so as to provide a rich source of bioavailable cysteine.
Immunocal® can thus be viewed as a cysteine delivery system.
The disulphide bond in cystine is pepsin and trypsin resistant but may be split by heat, low pH or mechanical stress releasing
free cysteine. When subject to heat or shearing forces (inherent in most extraction processes), the fragile disulfide bonds within
the peptides are broken and the bioavailability of cysteine is greatly diminished.
Glutathione is a tightly regulated intracellular constituent and is limited in its production by negative feedback inhibition of its
own synthesis through the enzyme gamma-glutamylcysteine synthetase, thus greatly minimizing any possibility of overdosage.
Glutathione has multiple functions:
1. It is the major endogenous antioxidant produced by the cells, participating directly in the neutralization of free radicals
and reactive oxygen compounds, as well as maintaining exogenous antioxidants such as vitamins C and E in their
reduced (active) forms.
2. Through direct conjugation, it detoxifies many xenobiotics (foreign compounds) and carcinogens, both organic and
3. It is essential for the immune system to exert its full potential, e.g. (1) modulating antigen presentation to lymphocytes,
thereby influencing cytokine production and type of response (cellular or humoral) that develops, (2) enhancing
proliferation of lymphocytes thereby increasing magnitude of response, (3) enhancing killing activity of cytotoxic T cells
and NK cells, and (4) regulating apoptosis, thereby maintaining control of the immune response.
4. It plays a fundamental role in numerous metabolic and biochemical reactions such as DNA synthesis and repair, protein
synthesis, prostaglandin synthesis, amino acid transport and enzyme activation. Thus, every system in the body can be
affected by the state of the glutathione system, especially the immune system, the nervous system, the gastrointestinal
system and the lungs.
Glutathione augmentation is a strategy developed to address states of glutathione deficiency, high oxidative stress, immune
deficiency, and xenobiotic overload in which glutathione plays a part in the detoxification of the xenobiotic in question.
Glutathione deficiency states include, but are not limited to: HIV/AIDS, infectious hepatitis, certain types of cancers, cataracts,
Alzheimer’s Disease, Parkinsons, chronic obstructive pulmonary disease, asthma, radiation, poisoning by acetominophen and
related agents, malnutritive states, arduous physical stress, aging, and has been associated with sub-optimal immune response.
Many clinical pathologies are associated with oxidative stress and are elaborated upon in numerous medical references.
Low glutathione is also strongly implicated in wasting and negative nitrogen balance, notably as seen in cancer, AIDS, sepsis,
trauma, burns and even athletic overtraining. Cysteine supplementation can oppose this process and in AIDS, for example,
result in improved survival rates.
- Milk Thistle Information for Consumers
- Milk Thistle Information for Healthcare Professionals (includes dosage details)
- Side Effects of Milk Thistle (detailed)
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