I need some comments from others who have used fluorouracil on their lips?
Question posted by jobradley on 13 Jan 2017
Last updated on 10 December 2021 by Jimbo4312
Middle of week 3 right now. 2 weeks of twice/day application of 5% Flourouracil on affected area of bottom lip. So I did half of the bottom lip and glad I didn't do the whole lip because it is uncomfortable. Blister almost the length of the half lip and 1/8" wide formed, with a couple peninsulas the size of petit peas formed by day 7. One the the peninsulas is where I'd recently had a broken blood vessel, which prompted the Dr. visit. I applied a thin layer of cream and wiped the upper lip with a damp kleenex repeatedly over the next hour or so to prevent transfer there. I stopped the treatment on day 13, one application early but the reaction coasted on till the blister was 1/4" wide and weeping, another 4 days or so. Mornings, I'd wake with orange scabs, which would melt away in an hour or so. Not too hideous looking. Now, day 23, the sore is fading - I even ate a bagel sandwich today as I can open my mouth wider without worrying about stretching the lip.
The suffering was fairly mild, imagine a persistent dry split lip, and worth the trouble if the pre-cancerous cells have indeed died off. I may do the the other half of the bottom lip but will wait for guidance from the derm. I should add that my communication with the derm was nill, as I have an HMO and a girl with an IPhone photographed my lip, resulting in a prescription from a remote derm, through my primary. I'd recommend this procedure. I bit more concerning if you have a lip issue but doing one half lip at a time seems a good approach. One derm I read online - "A yard is hard. An inch is a cinch." I need to start on my face too and will take a gradual approach there too as opposed to doing the whole face at once. Wait for winter to keep from warm sun.
Well this should cheer everyone up. I had actintic Chelitis on my lips. I was given a treatment of Fluorourail 5 for 12 days. It burned, blistered, hurt like anything and looked gross. A month later my lips still burned. Dr said it takes time. Went back after 3 months post treatment and now my lips, tongue and inside my mouth were burning. Dr gave me cream samples. After 6 months post treatment I went to a different Dermatologist. He said I had an infection and gave Cipro. Several months after that went to Neurologist and he just wanted to know how much this burning actually effected my life. (Not kidding) Over a year after treatment I went back to the first Derma Dr, he told me it is either a vitamin decrease, angry mouth syndrome or I need psychiatric care. He finally did a biopsy. ( again not kidding) ON my recent return visit the biopsy showed a dermatitis. He said it "could" be from medication I am on, but not the flourouracil treatment.
I'm 69 years old and never had an issue like this until after that treatment. I'm going to keep looking for an answer and a treatment. I have been left with burning lips, mouth and tongue for over 15 months now.
I have finished treating my lower lip with a mixture of 5-FU mixed with Calcipotriene. By adding the second ingredient the treatment is accelerated and more effective. I treated my lower lip with 2 applications per day for 7 days. By the 5th day there was a marked reaction and the skin surface broke down on day 7. I'm now on day 5 of post and the pain and discomfort have been extreme. Aquafor is essential to keep the tissue moist. I used this same method on my scalp with an excellent result. I highly recommend this protocol
I have read the comments about using Fluorouracil on your lips. Are you using 5% or .5%? My prescription is .5%. This is my first day but I am getting nervous with the reviews. Would appreciate comments.
I just finished my two week dosage around my lips and nose. The dermotologist told me NOT to put it directly on my lips but to put it between the nose and lip and then under the lower lip and, somehow, it goes to the lips. and it did. I only had cancer on my lower lip and it made my lip raw and swollen but not it is better. Also put it on my nose and now have beet red spots on nose, below and above lip. But do not put it directly on your lips also because you do NOT want to get it in your mouth.
- Fluorouracil uses and safety info
- Fluorouracil information for Healthcare Professionals (includes dosage details)
- Side effects of Fluorouracil (detailed)
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.