Absorption of an oral dose is rapid and consistent but incomplete. Approximately 50% of an oral dose is absorbed from the gastrointestinal tract, the remainder being excreted unchanged in the feces. Peak blood levels are reached between two (2) and four (4) hours after ingestion. Over 85% of an intravenous dose is excreted in urine within 24 hours compared with approximately 50% for an oral dose.
The elimination half-life of oral atenolol is approximately 6 to 7 hours. Following intravenous administration, peak plasma levels are reached within 5 minutes. Declines from peak levels are rapid (5- to 10-fold) during the first 7 hours; thereafter, plasma levels decay with a half-life similar to that of orally administered drug. Following oral doses of 50 mg or 100 mg, both beta-blocking and antihypertensive effects persist for at least 24 hours.
- Atenolol Information for Consumers
- Atenolol Information for Healthcare Professionals (includes dosage details)
- Side Effects of Atenolol (detailed)
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
Posted 24 Nov 2009 • 1 answer
Posted 13 Jun 2013 • 1 answer
Posted 5 Oct 2014 • 1 answer
Posted 4 Mar 2016 • 0 answers
Posted 21 May 2016 • 0 answers