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Zebeta Side Effects

Generic Name: bisoprolol

Note: This page contains side effects data for the generic drug bisoprolol. It is possible that some of the dosage forms included below may not apply to the brand name Zebeta.

In Summary

More frequent side effects include: fatigue. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to bisoprolol: oral tablet

As well as its needed effects, bisoprolol (the active ingredient contained in Zebeta) may cause unwanted side effects that require medical attention.

Severity: Major

If any of the following side effects occur while taking bisoprolol, check with your doctor immediately:

Less common:
  • Body aches or pain
  • chest pain
  • chills
  • cough
  • difficult or labored breathing
  • ear congestion
  • fever
  • headache
  • loss of voice
  • nasal congestion
  • pain or tenderness around eyes and cheekbones
  • shortness of breath or troubled breathing
  • sneezing
  • sore throat
  • stuffy or runny nose
  • tightness in chest
  • unusual tiredness or weakness
  • wheezing
Rare:
  • Chest discomfort
  • lightheadedness, dizziness, or fainting
  • slow or irregular heartbeat

If any of the following symptoms of overdose occur while taking bisoprolol, get emergency help immediately:

Symptoms of overdose:
  • Anxiety
  • blurred vision
  • cold sweats
  • coma
  • confusion
  • cool, pale skin
  • decreased urine output
  • depression
  • dilated neck veins
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • extreme fatigue
  • fast heartbeat
  • increased hunger
  • irregular breathing
  • nausea
  • nervousness
  • nightmares
  • noisy breathing
  • seizures
  • shakiness
  • slurred speech
  • sweating
  • swelling of face, fingers, feet, or lower legs
  • weight gain

Severity: Minor

Some bisoprolol side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common:
  • Abnormal or decreased touch sensation
  • diarrhea
  • difficulty in moving
  • lack or loss of strength
  • muscle pain or stiffness
  • pain in joints
  • sleeplessness
  • trouble sleeping
  • unable to sleep
  • vomiting

For Healthcare Professionals

Applies to bisoprolol: oral tablet

General

The more commonly reported side effects observed with this drug are bradycardia, dizziness, and hypotension.[Ref]

Cardiovascular

Bradycardia occurred as a dose-related event.

Cardiac failure occurred in 18.4% of patients (n=1328) compared with 22.8% of placebo-treated patients (n=1321).[Ref]

Very common (10% or more): Bradycardia (up to 15.2%)
Common (1% to 10%): Chest pain, heart failure aggravation, hypotension, cold extremities, peripheral edema, ischemia, conduction disorder, left cardiac failure, palpitation, vein disorder
Uncommon (0.1% to 1%): Atrioventricular (AV) disturbances, orthostatic hypotension
Frequency not reported: Other rhythm disturbances, claudication[Ref]

Nervous system

Very common (10% or more): Dizziness (up to 13.3%)
Common (1% to 10%): Headache, extremity numbness, cerebrovascular disorder, syncope, hypoesthesia
Frequency not reported: Vertigo, paresthesia, hypoesthesia, hyperesthesia, somnolence, decreased concentration/memory, tremor, taste abnormalities
Postmarketing reports: Unsteadiness[Ref]

Respiratory

Very common (10% or more): Dyspnea (up to 13.8%)
Common (1% to 10%): Pneumonia, bronchitis, coughing, exertional dyspnea, upper respiratory tract infection, respiratory distress, stridor, respiratory tract edema, respiratory tract hemorrhage, sinusitis
Uncommon (0.1% to 1%): Bronchospasm
Rare (0.01% to 0.1%): Allergic rhinitis[Ref]

Sinusitis occurred as a dose-related event.[Ref]

Immunologic

Very common: Antinuclear antibody (ANA) conversions (up to 15%)
Common (1% to 10%): Viral infection[Ref]

Dermatologic

Common (1% to 10%): Pruritus
Uncommon (0.1% to 1%): Sweating
Rare (0.01% to 0.1%): Itching, flushing, rash
Very rare (less than 0.01%): Alopecia, psoriasis-like rash, psoriasis exacerbation
Frequency not reported: Acne, eczema, skin irritation, cutaneous vasculitis
Postmarketing reports: Dermatitis, exfoliative dermatitis[Ref]

Gastrointestinal

Diarrhea occurred as a dose-related event.[Ref]

Common (1% to 10%): Nausea, vomiting, diarrhea, constipation, dyspepsia, epigastric pain (not food related), abdominal pain, gastritis, dry mouth
Frequency not reported: Gastric pain, peptic ulcer[Ref]

Metabolic

Common (1% to 10%): Purine metabolism disorder, carbohydrate metabolism disturbed, weight changes, cholesterol changes, potassium levels altered, blood lipid changes
Rare (0.01% to 0.1%): Increased triglycerides
Frequency not reported: Gout
Postmarketing reports: Increased uric acid and glucose[Ref]

Uric acid, serum potassium, glucose, and phosphorus increases associated with use of this drug were not of clinical importance and rarely resulted in discontinuation.[Ref]

Musculoskeletal

Common (1% to 10%): Limb pain, myalgia, arthropathy, arthralgia
Uncommon (0.1% to 1%): Muscular weakness, cramps
Frequency not reported: Back pain, neck pain, twitching[Ref]

Other

Common (1% to 10%): Asthenia, fatigue, body pain, fever, malaise
Rare (0.01% to 0.1%): Hearing disorders
Frequency not reported: Earache, tinnitus[Ref]

Fatigue and asthenia occurred as dose-related events.[Ref]

Psychiatric

Common (1% to 10%): Insomnia, anxiety
Uncommon (0.1% to 1%): Sleep disorders, depression
Rare (0.01% to 0.1%): Nightmares, hallucinations
Frequency not reported: Restlessness[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection
Rare (0.01% to 0.1%): Potency disorders
Frequency not reported: Decreased libido, Peyronie's disease, polyuria[Ref]

Hepatic

Common (1% to 10%): Hepatomegaly
Rare (0.01% to 0.1%): Increased liver enzymes (ALT, AST), hepatitis[Ref]

Transaminase elevations of 1 to 2 times the upper limit of normal were reported in 6.2% of patients, with a multiple occurrence rate of 1.9%. Generally, this increase was the result of underlying disorders or resolved with continued use of this drug.[Ref]

Hypersensitivity

Rare (0.01% to 0.1%): Hypersensitivity
Postmarketing reports: Angioedema[Ref]

Of the 15% of patients who developed positive ANA status, one-third of patients converted back to a negative titer with continued use.[Ref]

Ocular

Rare (0.01% to 0.1%): Reduced tear flow
Very rare (less than 0.01%): Conjunctivitis
Frequency not reported: Visual disturbances, ocular pain, ocular pressure[Ref]

Renal

Creatinine and BUN were associated with slightly increased levels, but these effects were generally not of clinical importance and rarely resulted in discontinuation.[Ref]

Frequency not reported: Cystitis, renal colic
Postmarketing reports: Increased creatinine and BUN[Ref]

Hematologic

During treatment with this drug, decreased levels of WBCs and platelets were not of clinical importance and rarely resulted in discontinuation.[Ref]

Postmarketing reports: Purpura, decreases in WBC and platelets[Ref]

References

1. "Product Information. Zebeta (bisoprolol)." Lederle Laboratories, Wayne, NJ.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

It is possible that some side effects of Zebeta may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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