User Reviews for Phenylephrine

phenylephrine for Nasal Congestion: I just searched peer-reviewed journals and found NO EVIDENCE SUPPORTING THE EFFECTIVENESS OF PHENYLEPHRINE. "Phenylephrine, at the FDA-approved dose of 10 mg for adults, is unlikely to provide relief of nasal congestion. It has poor oral bioavailability because of extensive first-pass metabolism in the gut and liver.3 Only 38% of the dose reaches the systemic circulation,3 compared with 90% of a pseudoephedrine dose.4 Moreover, in a randomized, double blind, placebo-controlled, crossover study of 3 oral decongestants in 20 patients with chronic nasal stuffiness, phenylephrine was no more effective than placebo in reducing nasal airway resistance" From the Department of Pharmacy Practice, College of Pharmacy, University of Florida, and the Drug Information Center, Shands Hospital at the University of Florida, Gainesville, Fla

phenylephrine for Nasal Congestion: What is the evidence that phenylephrine hydrochloride is effective as a decongenstant -- and at what dosages? Please cite one or more sources published in peer-reviewed journals. I ask only because I have heard rumors that at the 10 mg. dose it is no more effective than a placebo.

phenylephrine for Nasal Congestion: After 125 standard allergy tests and told "no reaction" I was pronounced as having "chronic non-allergic vasomotor rhinitis". I truly believe that my biggest problem was from corticosteroid nasal sprays prescribed, but never overused. I've found phenylephrine has helped in a variable increased dose. When the wind blows primarily in the fall, whatever is out there causes my problem. If I take 2 10mg to start my day, I'm in good shape with the regular dose the rest of the day.