Travatan Z Side Effects
Generic name: travoprost ophthalmic
Note: This document contains side effect information about travoprost ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name Travatan Z.
Some side effects of Travatan Z may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to travoprost ophthalmic: ophthalmic solution
Get emergency medical help if you have any of these signs of an allergic reaction while taking travoprost ophthalmic (the active ingredient contained in Travatan Z) hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using travoprost ophthalmic and call your doctor at once if you have any of these serious side effects:
redness, swelling, itching, or pain in or around your eye;
oozing or discharge from your eye;
increased sensitivity to light;
vision changes; or
Less serious side effects of travoprost ophthalmic may include:
mild eye discomfort;
feeling like something is in your eye;
dry or watery eyes; or
stinging or burning of the eyes after using the drops.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to travoprost ophthalmic: ophthalmic solution
Ocular side effects have most frequently included ocular hyperemia (35% to 50%). Decreased visual acuity, eye discomfort, foreign body sensation, pain and pruritus have been reported in 5% to 10% of patients. Abnormal vision, blepharitis, blurred vision, cataract, cells, conjunctivitis, dry eye, eye disorder, flare, iris discoloration, keratitis, lid margin crusting, photophobia, subconjunctival hemorrhage, and tearing have been reported in 1% to 4% of patients. Increased brown pigmentation of the iris and macular edema, including cystoid macular edema, have also been reported. In postmarketing use with prostaglandin analogs, periorbital and lid changes including deepening of the eyelid sulcus have been observed.
Travoprost can increase the amount of brown pigment in the eye by stimulating melanin production in melanocytes. The change in eye color occurs gradually over months to years and may be permanent. The entire or parts of the iris may be affected. Changes may be more prominent in patients with green-brown, blue/gray-brown or yellow-brown irides.
The manufacturer reports discontinuation of therapy due to conjunctival hyperemia in approximately 3% of patients.
A single case of poliosis was reported after 4 months of therapy. The affected lashes were interspersed with normally pigmented lashes. Hypertrichosis was also reported with this patient.
Dermatologic side effects have included increases in length, thickness, pigmentation, and/or number of eyelashes. Increased brown pigmentation of the eyelashes, periorbital, and/or eyelid tissue of the treated eye have also been reported. A single case of poliosis has been reported.
Cardiovascular side effects have included angina pectoris, bradycardia, chest pain, hypertension, and hypotension in less than 5% of patients.
A 34-year-old woman receiving travoprost ophthalmic (the active ingredient contained in Travatan Z) solution for open-angle glaucoma experienced abdominal cramps approximately 30 minutes following administration and lasting for approximately 2 hours in duration. The patient continued to report a similar experience with 3 rechallenges of travoprost, and patient-blind challenges using disguised delivery containers. The patient failed to experience abdominal cramps when undergoing a blind challenge with latanoprost.
Gastrointestinal side effects have included dyspepsia and gastrointestinal disorder in less than 5% of patients. Abdominal cramps have rarely been reported (1 case report).
Genitourinary side effects have included prostate disorder, urinary incontinence, and urinary tract infection in less than 5% of patients.
Musculoskeletal side effects have included arthritis and back pain in less than 5% of patients.
Nervous system side effects have included anxiety and headache in less than 5% of patients.
Respiratory side effects have included bronchitis, cold syndrome and sinusitis in less than 5% of patients.
Metabolic side effects have included hypercholesterolemia (<5%).
Other side effects have included accidental injury and pain in less than 5% of patients.
Psychiatric side effects have included depression (<5%).
Immunologic side effects have included infection (<5%).
More Travatan Z resources
- Travatan Z Consumer Overview
- Travatan Z drops MedFacts Consumer Leaflet (Wolters Kluwer)
- Travatan Prescribing Information (FDA)
- Travatan Monograph (AHFS DI)
- Travatan Advanced Consumer (Micromedex) - Includes Dosage Information
- Travatan Consumer Overview
- Travatan Drops MedFacts Consumer Leaflet (Wolters Kluwer)
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