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Travatan Z Side Effects

Generic Name: travoprost ophthalmic

Note: This page contains side effects data for the generic drug travoprost ophthalmic. It is possible that some of the dosage forms included below may not apply to the brand name Travatan Z.

It is possible that some side effects of Travatan Z may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to travoprost ophthalmic: ophthalmic solution

As well as its needed effects, travoprost ophthalmic (the active ingredient contained in Travatan Z) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking travoprost ophthalmic, check with your doctor immediately:

More common
  • Eye pain
  • itching eye
  • redness of the eye
  • redness, swelling, or itching of eyelid
Less common
  • Blurred or decreased vision
  • burning, dry, or itching eyes
  • eye color changes
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid

Some travoprost ophthalmic side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Eye discomfort
  • feeling of having something in the eye
Less common
  • Acid or sour stomach (heartburn or indigestion)
  • blood in the urine
  • chest pain or tightness
  • dry eyes
  • eye discharge or excessive tearing
  • faintness or lightheadedness when getting up from a lying or sitting position
  • loss of bladder control
  • lower back pain
  • muscle pain or stiffness
  • pain, swelling, or redness in the joints
  • pain or burning while urinating
  • pelvic pain
  • slow or irregular heartbeat (less than 50 beats per minute)

For Healthcare Professionals

Applies to travoprost ophthalmic: ophthalmic solution


Ocular side effects have most frequently included ocular hyperemia (35% to 50%). Decreased visual acuity, eye discomfort, foreign body sensation, pain and pruritus have been reported in 5% to 10% of patients. Abnormal vision, blepharitis, blurred vision, cataract, cells, conjunctivitis, dry eye, eye disorder, flare, iris discoloration, keratitis, lid margin crusting, photophobia, subconjunctival hemorrhage, and tearing have been reported in 1% to 4% of patients. Increased brown pigmentation of the iris and macular edema, including cystoid macular edema, have also been reported. In postmarketing use with prostaglandin analogs, periorbital and lid changes including deepening of the eyelid sulcus have been observed.[Ref]

Travoprost can increase the amount of brown pigment in the eye by stimulating melanin production in melanocytes. The change in eye color occurs gradually over months to years and may be permanent. The entire or parts of the iris may be affected. Changes may be more prominent in patients with green-brown, blue/gray-brown or yellow-brown irides.

The manufacturer reports discontinuation of therapy due to conjunctival hyperemia in approximately 3% of patients.[Ref]


A single case of poliosis was reported after 4 months of therapy. The affected lashes were interspersed with normally pigmented lashes. Hypertrichosis was also reported with this patient.[Ref]

Dermatologic side effects have included increases in length, thickness, pigmentation, and/or number of eyelashes. Increased brown pigmentation of the eyelashes, periorbital, and/or eyelid tissue of the treated eye have also been reported. A single case of poliosis has been reported.[Ref]


Cardiovascular side effects have included angina pectoris, bradycardia, chest pain, hypertension, and hypotension in less than 5% of patients.[Ref]


A 34-year-old woman receiving travoprost ophthalmic (the active ingredient contained in Travatan Z) solution for open-angle glaucoma experienced abdominal cramps approximately 30 minutes following administration and lasting for approximately 2 hours in duration. The patient continued to report a similar experience with 3 rechallenges of travoprost, and patient-blind challenges using disguised delivery containers. The patient failed to experience abdominal cramps when undergoing a blind challenge with latanoprost.[Ref]

Gastrointestinal side effects have included dyspepsia and gastrointestinal disorder in less than 5% of patients. Abdominal cramps have rarely been reported (1 case report).[Ref]


Genitourinary side effects have included prostate disorder, urinary incontinence, and urinary tract infection in less than 5% of patients.[Ref]


Musculoskeletal side effects have included arthritis and back pain in less than 5% of patients.[Ref]

Nervous system

Nervous system side effects have included anxiety and headache in less than 5% of patients.[Ref]


Respiratory side effects have included bronchitis, cold syndrome and sinusitis in less than 5% of patients.[Ref]


Metabolic side effects have included hypercholesterolemia (<5%).[Ref]


Other side effects have included accidental injury and pain in less than 5% of patients.[Ref]


Psychiatric side effects have included depression (<5%).[Ref]


Immunologic side effects have included infection (<5%).[Ref]


1. Wand M, Shields BM "Cystoid macular edema in the era of ocular hypotensive lipids." Am J Ophthalmol 133 (2002): 393-7

2. Wand M, Gaudio AR "Cystoid macular edema associated with ocular hypotensive lipids." Am J Ophthalmol 133 (2002): 403-5

3. "Product Information. Travatan (travoprost ophthalmic)" Alcon Laboratories Inc, Fort Worth, TX.

4. "Two new ophthalmic solutions enter glaucoma market." Am J Health Syst Pharm 58 (2001): 1080, 1086

5. Stewart WC, Kolker AE, Stewart JA, Leech J, Jackson AL "Conjunctival hyperemia in healthy subjects after short-term dosing with latanoprost, bimatoprost, and travoprost." Am J Ophthalmol 135 (2003): 314-20

6. Chen CS, Wells J, Craig JE "Topical prostaglandin F(2alpha) analog induced poliosis." Am J Ophthalmol 137 (2004): 965-6

7. Lee YC "Abdominal cramp as an adverse effect of travoprost." Am J Ophthalmol 139 (2005): 202-203

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