Timolol Side Effects
Some side effects of timolol may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to timolol: oral tablet
Along with its needed effects, timolol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking timolol:More common
- Chest pain or discomfort
- lightheadedness, dizziness, or fainting
- shortness of breath
- slow or irregular heartbeat
- unusual tiredness
- Difficult or labored breathing
- fast heartbeat
- tightness in chest
- Noisy breathing
- small clicking, bubbling, or rattling sounds in the lung when listening with a stethoscope
- swelling of hands, ankles, feet, or lower legs
Get emergency help immediately if any of the following symptoms of overdose occur while taking timolol:Symptoms of overdose
- Blurred vision
- continuing ringing or buzzing or other unexplained noise in ears
- hearing loss
- pounding in the ears
Some side effects of timolol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Less common
- Itching skin
- red, sore eyes
- Acid or sour stomach
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- decreased interest in sexual intercourse
- feeling of constant movement of self or surroundings
- inability to have or keep an erection
- lack or loss of strength
- loss in sexual ability, desire, drive, or performance
- sensation of spinning
- stomach discomfort, upset, or pain
For Healthcare Professionals
Applies to timolol: compounding powder, oral tablet
Cardiovascular side effects are the most common. Sinus bradycardia is reported in 9% of patients. Atrioventricular conduction disturbances, hypotension, and exacerbation of congestive heart failure are reported in less than 1% of patients.
Respiratory problems associated with timolol, like with other beta antagonists, include bronchial constriction in susceptible patients. Dyspnea is reported in 6% of patients.
Alternative therapy should be considered in patients with reactive airways disease. Cases of fatal respiratory arrest are reported in patients with asthma, even after topically administered timolol.
Nervous system side effects include fatigue in 6%, headache in 4%, and dizziness in 6% of treated patients. Cases of visual hallucinations, insomnia and depression have been reported rarely. Timolol may worsen myasthenia gravis.
A case of amaurosis fugax is associated with timolol. However, the patient involved had underlying cerebrovascular disease, autonomic dysfunction, and an arrhythmia.
Endocrinologic side effects of timolol include masking the signs and symptoms and blunting the normal physiologic response to hypoglycemia. Timolol may cause an increase in serum triglycerides, LDL cholesterol, and VLDL cholesterol, and a decrease in HDL cholesterol.
Alternative therapy should be considered in patients with diabetes mellitus who are prone to hypoglycemia.
Psychiatric side effects, such as confusion, depression (including acute suicidal ideation), vivid and frightening dreams, and visual hallucinations are reported in rare cases.
Sexual dysfunction is reported from questionnaires, although the questions may have biased the data since the responses were not spontaneous.
Gastrointestinal complaints of general abdominal pain, nausea, constipation, or diarrhea are reported in 1% to 5% of patients.
Dermatologic side effects are unusual. Rare cases of generalized psoriasis and hyperpigmented nailbeds are reported.
Genitourinary complaints of impotence and decreased libido are rare.
Musculoskeletal side effects are rare. Timolol may worsen myasthenia gravis.
General side effects including decreased exercise tolerance, extremity pain, weight loss and fever have been reported.
Hypersensitivity reactions including anaphylaxis have been reported in clinical experience with timolol.
More timolol resources
- timolol Concise Consumer Information (Cerner Multum)
- timolol Advanced Consumer (Micromedex) - Includes Dosage Information
- timolol MedFacts Consumer Leaflet (Wolters Kluwer)
- Timolol eent Monograph (AHFS DI)
- Timolol Prescribing Information (FDA)
- Blocadren Prescribing Information (FDA)
- Timolol Maleate Monograph (AHFS DI)
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