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Ticagrelor Side Effects

It is possible that some side effects of ticagrelor may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to ticagrelor: oral tablet

As well as its needed effects, ticagrelor may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking ticagrelor, check with your doctor immediately:

More common
  • Difficult or labored breathing
  • shortness of breath
  • tightness in the chest
Less common
  • Blurred vision
  • chest pain or discomfort
  • confusion
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • fast or irregular heartbeat
  • headache
  • lightheadedness, dizziness, or fainting
  • loss of consciousness
  • nervousness
  • pounding in the ears
  • slow or fast heartbeat
  • sweating
  • unusual tiredness or weakness
Incidence not known
  • Bleeding gums
  • bruising
  • coughing up blood
  • difficulty with breathing or swallowing
  • headache, sudden and severe
  • increased menstrual flow or vaginal bleeding
  • nausea or vomiting
  • nosebleeds
  • paralysis
  • prolonged bleeding from cuts
  • red or black, tarry stools
  • red or dark brown urine
  • weakness

Some ticagrelor side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common
  • Back pain
  • cough
  • diarrhea
  • Swelling of the breasts or breast soreness in both females and males

For Healthcare Professionals

Applies to ticagrelor: oral tablet


Hematologic side effects have included fatal/life-threatening bleeding such as intracranial; intrapericardial bleed with cardiac tamponade; hypovolemic shock or severe hypotension due to bleeding and requiring pressors or surgery; clinically overt or apparent bleeding associated with a decrease in hemoglobin (Hb) of more than 5 g/dL; transfusion of 4 or more units (whole blood or packed red blood cells (PRBCs)) for bleeding; major bleeding such as significantly disabling (e.g., intraocular with permanent vision loss); clinically overt or apparent bleeding associated with a decrease in Hb of 3 g/dL; transfusion of 2 to 3 units (whole blood or PRBCs) for bleeding; minor bleeding which requires medical intervention to stop or treat bleeding (e.g., epistaxis requiring visit to medical facility for packing); minimal bleeding such as bruising, bleeding gums, oozing from injection sites, not requiring intervention or treatment.[Ref]


Cardiovascular side effects have included atrial fibrillation, hypertension, hypotension, chest pain, and bradycardia.[Ref]


Musculoskeletal side effects have included noncardiac chest pain and back pain.[Ref]

Nervous system

Nervous system side effects have included headache and dizziness.[Ref]


Respiratory side effects have included cough, dyspnea, exertional dyspnea, dyspnea at rest, nocturnal dyspnea, and paroxysmal nocturnal dyspnea.[Ref]


Gastrointestinal side effects have include nausea and diarrhea.[Ref]


General side effects have included fatigue.[Ref]


Endocrine side effects have included gynecomastia.[Ref]


Hypersensitivity side effects have included postmarketing reports of hypersensitivity reactions including angioedema.


1. "Product Information. Brilinta (ticagrelor)." Astra-Zeneca Pharmaceuticals, Wilmington, DE.

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