Sprycel Side Effects
Generic Name: dasatinib
Note: This document contains side effect information about dasatinib. Some of the dosage forms listed on this page may not apply to the brand name Sprycel.
Some side effects of Sprycel may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to dasatinib: oral tablet
Along with its needed effects, dasatinib (the active ingredient contained in Sprycel) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking dasatinib:More common
- Bloody or black, tarry stools
- body aches or pain
- burning, tingling, numbness or pain in the hands, arms, feet, or legs
- chest pain
- cough or hoarseness
- coughing up blood
- decrease in the amount of urine
- difficulty with breathing
- ear congestion
- fast, slow, or irregular heartbeat
- fever or chills
- full or bloated feeling
- loss of voice
- lower back or side pain
- nasal congestion
- noisy or rattling breathing
- painful or difficult urination
- pale skin
- pressure in the stomach
- runny nose
- sensation of pins and needles
- severe stomach pain
- shortness of breath
- sore throat
- stabbing pain
- swelling of the abdominal or stomach area
- swelling of the face, fingers, hands, feet, or lower legs
- tightness in the chest
- troubled breathing
- ulcers, sores, or white spots in the mouth
- unsteadiness or awkwardness
- unusual bleeding or bruising
- unusual tiredness or weakness
- vomiting of blood or material that looks like coffee grounds
- weakness in the arms, hands, legs, or feet
- weight gain
- blue lips and fingernails
- chest discomfort
- coughing that sometimes produces a pink frothy sputum
- decreased urine output
- difficult or fast breathing
- dilated neck veins
- increased sweating
- irregular breathing
- irregular heartbeat
- swelling in the legs and ankles
- pain, redness, or swelling in the arm or leg
- sudden shortness of breath or troubled breathing
- tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area
Some side effects of dasatinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Abdominal or stomach pain
- bleeding gums
- cracked lips
- difficulty with moving
- difficulty with swallowing
- increased menstrual flow or vaginal bleeding
- itching skin
- lack or loss of strength
- loss of appetite
- muscle aching or cramping
- muscle or bone pain
- muscle stiffness
- nose bleeds
- pain in the joints
- prolonged bleeding from cuts
- red or dark brown urine
- skin rash
- swelling or inflammation of the mouth
- swollen joints
- weight loss
For Healthcare Professionals
Applies to dasatinib: oral tablet
Hematologic side effects including neutropenia (up to 83%), thrombocytopenia (up to 83%), anemia (up to 70%), hemorrhage (40%), and febrile neutropenia (9%) have been reported. Pancytopenia has been reported frequently. Coagulopathy and pure red cell aplasia have been reported infrequently.
General side effects including pyrexia (39%), fatigue (39%), pain (26%) and abdominal pain (25%), asthenia (19%), mucosal inflammation (16%), dizziness (14%), decreased weight (14%), chest pain (13%), abdominal distention (11%), increased weight (11%), and chills (11%) have been reported. Malaise has been reported frequently. Temperature intolerance has been reported infrequently. Fluid retention (50%) has included superficial edema (36%), pleural effusion (22%), other fluid retention (14%), generalized edema (5%), and ascites (1%).
Gastrointestinal side effects including diarrhea (49%), nausea (34%), vomiting (22%), anorexia (19%), gastrointestinal bleeding (14%), and constipation (14%) have been reported. Dyspepsia, oral soft tissue disorder, gastritis, colitis, anal fissure, and dysphagia have been reported frequently. Esophagitis, upper gastrointestinal ulcer, ileus, and pancreatitis have been reported infrequently. . Severe gastrointestinal hemorrhage (4%), including fatalities, was reported and generally required treatment interruption and transfusion.
Nervous system side effects including headache (40%), neuropathy (including peripheral neuropathy) (13%), and CNS bleeding (2%) have been reported. Dysgeusia, somnolence, syncope, tremor, and convulsions have been reported frequently. Amnesia, cerebrovascular accident, transient ischemic attack, and reversible posterior leukoencephalopathy syndrome have been reported infrequently.
Musculoskeletal side effects including musculoskeletal pain (39%), arthralgia (19%), and myalgia (12%) have been reported. Muscle inflammation, muscular weakness, and musculoskeletal stiffness have been reported frequently. Tendonitis and rhabdomyolysis have been reported infrequently.
Respiratory side effects have included dyspnea (32%), cough (28%), upper respiratory tract infection/inflammation (26%), bacterial, viral, and fungal pneumonia (11%), pulmonary edema (4%), and pulmonary hypertension (1%). Lung infiltration, pneumonitis, and asthma have been reported frequently. Bronchospasm and acute respiratory distress syndrome have been reported infrequently.
Metabolic side effects including hypophosphatemia (up to 23%) and hypocalcemia (up to 20%) have been reported. Appetite disturbances and hyperuricemia have been reported frequently. Hypoalbuminemia has been reported infrequently.
Hepatic side effects including elevated SGPT (ALT) (up to 11%), elevated SGOT (AST) (up to 8%), elevated bilirubin (up to 8%), and elevated transaminase have been reported. Cholecystitis, cholestasis, and hepatitis have been reported infrequently.
Cardiovascular side effects including arrhythmia (11%) and pericardial effusion (4%) have been reported. Palpitations, flushing, hypotension, hypertension, angina pectoris, cardiomegaly, and myocardial infarction have been reported frequently. Pericarditis, ventricular tachycardia, acute coronary syndrome, myocarditis, and QT prolongation have been reported infrequently. Congestive heart failure/cardiac dysfunction (4%) has included ventricular dysfunction, cardiac failure, cardiac failure congestive, cardiomyopathy, congestive cardiomyopathy, ejection fraction decreased, and left ventricular failure.
Dermatologic side effects including pruritus (11%) have been reported. Hyperhidrosis, alopecia, dry skin, acne, urticaria, dermatitis (including eczema), photosensitivity reaction, nail disorder, and pigmentation disorder have been reported frequently. Skin ulcer, acute febrile neutrophilic dermatosis, bullous conditions, livedo reticularis, panniculitis, palmar-plantar erythrodysesthesia syndrome have been reported infrequently. Skin rash (35%) has included erythema, exfoliative rash, generalized erythema, milia, rash, erythematous rash, follicular rash, generalized rash, macular rash, maculopapular rash, papular rash, pruritic rash, pustular rash, skin exfoliation, systemic lupus erythematosus rash, vesiculosa urticaria, drug eruption, and vesicular rash.
Renal side effects including elevated creatinine (up to 2%) have been reported. Urinary frequency and renal failure have been reported frequently. Proteinuria has been reported infrequently.
Other side effects including infection (including bacterial, viral, fungal, non-specified), herpes virus infection, sepsis (including fatal outcomes), enterocolitis infection, tinnitus, vertigo, and contusion have been reported frequently. Blood creatine phosphokinase increased has also been reported.
Psychiatric side effects including insomnia, depression, anxiety, confusional state, and affect lability have been reported frequently. Decreased libido has been reported infrequently.
Genitourinary side effects including gynecomastia have been reported frequently. Irregular menstruation has been reported infrequently.
Hypersensitivity side effects have infrequently included erythema nodosum.
Ocular side effects including visual disorder, conjunctivitis, and dry eyes have been reported frequently.
Oncologic side effects including tumor lysis syndrome have been reported frequently.
More about Sprycel (dasatinib)
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