BCR-ABL tyrosine kinase inhibitors
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BCR-ABL tyrosine kinase inhibitors inhibit the enzyme BCR-ABL tyrosine kinase, which is important in the pathogenesis of chronic myelogenous leukemia (CML).
Chronic myelogenous leukemia occurs due a single genetic abnormality, known as the Philadelphia chromosome. During the translocation when the Philadelphia chromosome is created, a fusion gene called BCR-ABL gene is formed. The BCR-ABL gene encodes for the BCR-ABL tyrosine kinase. The BCR-ABL positive cells in chronic myelogenous leukemia have increased proliferation and resistance to cell death.
BCR-ABL tyrosine kinase inhibitors are used to treat chronic myelogenous leukemia.
|Drug Name ( View by: Brand | Generic )||Reviews||Ratings|
|Gleevec (Pro, More...)
generic name: imatinib
|Sprycel (Pro, More...)
generic name: dasatinib
|Tasigna (Pro, More...)
generic name: nilotinib
|Iclusig (Pro, More...)
generic name: ponatinib
|Bosulif (Pro, More...)
generic name: bosutinib
Medical conditions associated with BCR-ABL tyrosine kinase inhibitors: