Relistor Side Effects

Generic Name: methylnaltrexone

Note: This page contains side effects data for the generic drug methylnaltrexone. It is possible that some of the dosage forms included below may not apply to the brand name Relistor.

It is possible that some side effects of Relistor may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to methylnaltrexone: subcutaneous solution

As well as its needed effects, methylnaltrexone (the active ingredient contained in Relistor) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking methylnaltrexone, check with your doctor immediately:

More common
  • Diarrhea
  • increased sweating
Incidence not known
  • Bloody, black, or tarry stools
  • heartburn
  • indigestion
  • nausea
  • severe abdominal or stomach pain, cramping, or burning
  • trouble breathing
  • vomiting of material that looks like coffee grounds, severe and continuing

If any of the following symptoms of overdose occur while taking methylnaltrexone, get emergency help immediately:

Symptoms of overdose
  • Chills
  • cold sweats
  • confusion
  • dizziness, faintness, or lightheadedness when getting up from lying or sitting position

Some methylnaltrexone side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Bloated
  • dizziness
  • excess air or gas in the stomach or intestines
  • full feeling
  • passing gas
  • stomach pain

For Healthcare Professionals

Applies to methylnaltrexone: subcutaneous kit, subcutaneous solution

Gastrointestinal

Very common (10% or more): Abdominal pain (up to 29%), flatulence (up to 13%), nausea (up to 12%)
Common (1% to 10%): Diarrhea,
Postmarketing reports: Perforation, cramping, vomiting[Ref]

Nervous system

Common (1% to 10%): Dizziness, tremor[Ref]

Dermatologic

Common (1% to 10%): Hyperhidrosis, flushing[Ref]

Other

Common (1% to 10%): Chills
Postmarketing reports: Malaise, pain, cases of opioid withdrawal[Ref]

Cardiovascular

In an open-label, uncontrolled study (n=1034), 4 myocardial infarctions (1 fatal), 1 stroke (fatal), 1 fatal cardiac arrest, and 1 sudden death were reported. It is not possible to establish a relationship between these events and use of this drug.[Ref]

Frequency not reported: Myocardial infarctions[Ref]

General

The most common adverse reactions included abdominal pain, nausea, diarrhea, hyperhidrosis, hot flush, tremor, and chills.[Ref]

Local

Common (1% to 10%): Injection site reactions including stinging, burning, pain, redness, and edema[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Relistor (methylnaltrexone)." Wyeth Laboratories, Philadelphia, PA.

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